Note: The hazard category numbers found in GHS classification in section 2
of this SDSs are NOT to be used to fill in the NFPA 704 diamond. Blue =
Health Red = Fire Yellow = Reactivity White = Special (Oxidizer or water
reactive substances)
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Chemwatch Hazard Alert Code: 4
METYX USA, INC.
Version No: 7.8
Safety Data Sheet according to OSHA HazCom Standard (2012) requirements
Issue Date: 20/03/2023
Print Date: 20/03/2023
S.GHS.USA.EN
SECTION 1 Identification
Product Identifier
Product name METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Synonyms Not Available
Proper shipping name Aerosols, flammable, (each not exceeding 1 L capacity)
Other means of identificationNot Available
Recommended use of the chemical and restrictions on use
Relevant identified usesApplication is by spray atomisation from a hand held aerosol pack
Name, address, and telephone number of the chemical manufacturer, importer, or other responsible party
Registered company name METYX USA, INC.
Address 2504 Lowell Rd, Gastonia North Carolina 28054 United States
Telephone +1 (704) 824-1030
Fax Not Available
Website
Email info@metyxusa.com
Emergency phone number
Association / OrganisationCHEMWATCH EMERGENCY RESPONSE (24/7)
Emergency telephone
numbers
+1 855-237-5573
Other emergency telephone
numbers
+61 3 9573 3188
Once connected and if the message is not in your preferred language then please dial 01
Una vez conectado y si el mensaje no est en su idioma preferido, por favor marque 02
SECTION 2 Hazard(s) identification
Classification of the substance or mixture
Classification
Serious Eye Damage/Eye Irritation Category 2A, Specific Target Organ Toxicity – Single Exposure (Narcotic Effects) Category 3, Aerosols
Category 1, Skin Corrosion/Irritation Category 2, Hazardous to the Aquatic Environment Long-Term Hazard Category 3
Label elements
Hazard pictogram(s)
Signal word Danger
Hazard statement(s)
Not Available Page 1 continued…
CAS No Name
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
H222 Extremely flammable aerosol.
H315 Causes skin irritation.
H412 Harmful to aquatic life with long lasting effects.
Hazard(s) not otherwise classified
Not Applicable
Precautionary statement(s) Prevention
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P211 Do not spray on an open flame or other ignition source.
P251 Pressurized container: Do not pierce or burn, even after use.
P271 Use only outdoors or in a well-ventilated area.
P261 Avoid breathing gas.
P273 Avoid release to the environment.
P280 Wear protective gloves, protective clothing, eye protection and face protection.
P264 Wash all exposed external body areas thoroughly after handling.
Precautionary statement(s) Response
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER/doctor/physician/first aider/if you feel unwell.
P337+P313 If eye irritation persists: Get medical advice/attention.
P302+P352 IF ON SKIN: Wash with plenty of water and soap.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
Precautionary statement(s) Storage
P405 Store locked up.
P410+P412 Protect from sunlight. Do not expose to temperatures exceeding 50 C/122 F.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Precautionary statement(s) Disposal
P501 Dispose of contents/container to authorised hazardous or special waste collection point in accordance with any local regulation.
SECTION 3 Composition / information on ingredients
Substances
See section below for composition of Mixtures
Mixtures
%[weight]
79-20-9 20-40
64742-49-0* 5-25
106-97-8. 1-10
74-98-6 5-20
75-28-5. 1-10
75-37-6 5-20
The specific chemical identity and/or exact percentage (concentration) of composition has been withheld as a trade secret.
SECTION 4 First-aid measures
Description of first aid measures
Eye Contact
If aerosols come in contact with the eyes:
Immediately hold the eyelids apart and flush the eye continuously for at least 15 minutes with fresh running water.
Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper
and lower lids.
Transport to hospital or doctor without delay.
Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
Skin Contact
If solids or aerosol mists are deposited upon the skin:
Flush skin and hair with running water (and soap if available).
Remove any adhering solids with industrial skin cleansing cream.
methyl acetate
Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane
butane
propane
iso-butane
1,1-difluoroethane Version No: 7.8 Page 2 of 18
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Issue Date: 20/03/2023
Print Date: 20/03/2023 Continued...
DO NOT use solvents.
Seek medical attention in the event of irritation.
Inhalation
If aerosols, fumes or combustion products are inhaled:
Remove to fresh air.
Lay patient down. Keep warm and rested.
Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures.
If breathing is shallow or has stopped, ensure clear airway and apply resuscitation, preferably with a demand valve resuscitator, bag-valve
mask device, or pocket mask as trained. Perform CPR if necessary.
Transport to hospital, or doctor.
Ingestion
Immediately give a glass of water.
First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.
If spontaneous vomiting appears imminent or occurs, hold patient's head down, lower than their hips to help avoid possible aspiration of
vomitus.
Most important symptoms and effects, both acute and delayed
See Section 11
Indication of any immediate medical attention and special treatment needed
For petroleum distillates
In case of ingestion, gastric lavage with activated charcoal can be used promptly to prevent absorption - decontamination (induced emesis or lavage) is controversial and should be
considered on the merits of each individual case; of course the usual precautions of an endotracheal tube should be considered prior to lavage, to prevent aspiration.
Individuals intoxicated by petroleum distillates should be hospitalized immediately, with acute and continuing attention to neurologic and cardiopulmonary function.
Positive pressure ventilation may be necessary.
Acute central nervous system signs and symptoms may result from large ingestions of aspiration-induced hypoxia.
After the initial episode,individuals should be followed for changes in blood variables and the delayed appearance of pulmonary oedema and chemical pneumonitis. Such patients
should be followed for several days or weeks for delayed effects, including bone marrow toxicity, hepatic and renal impairment Individuals with chronic pulmonary disease will be more
seriously impaired, and recovery from inhalation exposure may be complicated.
Gastrointestinal symptoms are usually minor and pathological changes of the liver and kidneys are reported to be uncommon in acute intoxications.
Chlorinated and non-chlorinated hydrocarbons may sensitize the heart to epinephrine and other circulating catecholamines so that arrhythmias may occur.Careful consideration of
this potential adverse effect should precede administration of epinephrine or other cardiac stimulants and the selection of bronchodilators.
Treat symptomatically.
for simple esters:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
Establish a patent airway with suction where necessary.
Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Administer oxygen by non-rebreather mask at 10 to 15 l/min.
Monitor and treat, where necessary, for pulmonary oedema .
Monitor and treat, where necessary, for shock.
DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml water (5 ml/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
Give activated charcoal.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory arrest has occurred.
Positive-pressure ventilation using a bag-valve mask might be of use.
Monitor and treat, where necessary, for arrhythmias.
Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers solution. Fluid overload might create complications.
Drug therapy should be considered for pulmonary oedema.
Hypotension with signs of hypovolaemia requires the cautious administration of fluids. Fluid overload might create complications.
Treat seizures with diazepam.
Proparacaine hydrochloride should be used to assist eye irrigation.
--------------------------------------------------------------
EMERGENCY DEPARTMENT
--------------------------------------------------------------
Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine, glucose, urinalysis, baseline for serum aminotransferases (ALT and AST), calcium, phosphorus
and magnesium, may assist in establishing a treatment regime. Other useful analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs and
electrocardiograph.
Positive end-expiratory pressure (PEEP)-assisted ventilation may be required for acute parenchymal injury or adult respiratory distress syndrome.
Consult a toxicologist as necessary.
BRONSTEIN, A.C. and CURRANCE, P.L. EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994
For acute and short term repeated exposures to methanol:
Toxicity results from accumulation of formaldehyde/formic acid.
Clinical signs are usually limited to CNS, eyes and GI tract Severe metabolic acidosis may produce dyspnea and profound systemic effects which may become intractable. All
symptomatic patients should have arterial pH measured. Evaluate airway, breathing and circulation.
Stabilise obtunded patients by giving naloxone, glucose and thiamine.
Decontaminate with Ipecac or lavage for patients presenting 2 hours post-ingestion. Charcoal does not absorb well; the usefulness of cathartic is not established.
Forced diuresis is not effective; haemodialysis is recommended where peak methanol levels exceed 50 mg/dL (this correlates with serum bicarbonate levels below 18 mEq/L).
Ethanol, maintained at levels between 100 and 150 mg/dL, inhibits formation of toxic metabolites and may be indicated when peak methanol levels exceed 20 mg/dL. An intravenous
solution of ethanol in D5W is optimal.
Folate, as leucovorin, may increase the oxidative removal of formic acid. 4-methylpyrazole may be an effective adjunct in the treatment. 8.Phenytoin may be preferable to diazepam
for controlling seizure.
[Ellenhorn Barceloux: Medical Toxicology]
Methanol poisoning can be treated with fomepizole, or if unavailable, ethanol. Both drugs act to reduce the action of alcohol dehydrogenase on methanol by means of competitive
inhibition. Ethanol, the active ingredient in alcoholic beverages, acts as a competitive inhibitor by more effectively binding and saturating the alcohol dehydrogenase enzyme in the
liver, thus blocking the binding of methanol. Methanol is excreted by the kidneys without being converted into the very toxic metabolites formaldehyde and formic acid. Alcohol
dehydrogenase instead enzymatically converts ethanol to acetaldehyde, a much less toxic organic molecule. Additional treatment may include sodium bicarbonate for metabolic
acidosis, and hemodialysis or hemodiafiltration to remove methanol and formate from the blood. Folinic acid or folic acid is also administered to enhance the metabolism of formate.
BIOLOGICAL EXPOSURE INDEX - BEI
Determinant Index Sampling Time Comment
1. Methanol in urine 15 mg/l End of shift B, NS
2. Formic acid in urine 80 mg/gm creatinine Before the shift at end of workweek B, NS Version No: 7.8 Page 3 of 18
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Issue Date: 20/03/2023
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B: Background levels occur in specimens collected from subjects NOT exposed.
NS: Non-specific determinant - observed following exposure to other materials.
SECTION 5 Fire-fighting measures
Extinguishing media
Alcohol stable foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.
Water spray or fog - Large fires only.
SMALL FIRE:
Water spray, dry chemical or CO2
LARGE FIRE:
Water spray or fog.
Special hazards arising from the substrate or mixture
Fire Incompatibility Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result
Special protective equipment and precautions for fire-fighters
Fire Fighting
Fire/Explosion Hazard
carbon dioxide (CO2)
other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
BEWARE: Empty solvent, paint, lacquer and flammable liquid drums present a severe explosion hazard if cut by flame torch or welded. Even
when thoroughly cleaned or reconditioned the drum seams may retain sufficient solvent to generate an explosive atmosphere in the drum.
WARNING: Aerosol containers may present pressure related hazards.
SECTION 6 Accidental release measures
Personal precautions, protective equipment and emergency procedures
See section 8
Environmental precautions
See section 12
Methods and material for containment and cleaning up
Minor Spills
Clean up all spills immediately.
Avoid breathing vapours and contact with skin and eyes.
Wear protective clothing, impervious gloves and safety glasses.
Shut off all possible sources of ignition and increase ventilation.
Wipe up.
If safe, damaged cans should be placed in a container outdoors, away from all ignition sources, until pressure has dissipated.
Undamaged cans should be gathered and stowed safely.
Major Spills
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water courses
No smoking, naked lights or ignition sources.
Increase ventilation.
Stop leak if safe to do so.
Water spray or fog may be used to disperse / absorb vapour.
Absorb or cover spill with sand, earth, inert materials or vermiculite.
If safe, damaged cans should be placed in a container outdoors, away from ignition sources, until pressure has dissipated.
Undamaged cans should be gathered and stowed safely.
Collect residues and seal in labelled drums for disposal.
Personal Protective Equipment advice is contained in Section 8 of the SDS.
SECTION 7 Handling and storage
Precautions for safe handling
Safe handling
The conductivity of this material may make it a static accumulator., A liquid is typically considered nonconductive if its conductivity is below 100
pS/m and is considered semi-conductive if its conductivity is below 10 000 pS/m., Whether a liquid is nonconductive or semi-conductive, the
precautions are the same., A number of factors, for example liquid temperature, presence of contaminants, and anti-static additives can greatly
influence the conductivity of a liquid.
Radon and its radioactive decay products are hazardous if inhaled or ingested
Avoid all personal contact, including inhalation.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Prevent concentration in hollows and sumps.
DO NOT enter confined spaces until atmosphere has been checked.
Avoid smoking, naked lights or ignition sources.
Avoid contact with incompatible materials. Version No: 7.8 Page 4 of 18
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Issue Date: 20/03/2023
Print Date: 20/03/2023 Continued...
Source Ingredient Material name TWA STEL Peak NotesWhen handling, DO NOT eat, drink or smoke.
DO NOT incinerate or puncture aerosol cans.
DO NOT spray directly on humans, exposed food or food utensils.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately.
Use good occupational work practice.
Observe manufacturer's storage and handling recommendations contained within this SDS.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are maintained.
Other information
Conditions for safe storage, including any incompatibilities
Suitable container
For low viscosity materials (i) : Drums and jerry cans must be of the non-removable head type. (ii) : Where a can is to be used as an inner
package, the can must have a screwed enclosure.
For materials with a viscosity of at least 2680 cSt. (23 deg. C)
For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
Manufactured product that requires stirring before use and having a viscosity of at least 20 cSt (25 deg. C): (i) Removable head packaging;
(ii) Cans with friction closures and (iii) low pressure tubes and cartridges may be used.
Where combination packages are used, and the inner packages are of glass, there must be sufficient inert cushioning material in contact with
inner and outer packages
In addition, where inner packagings are glass and contain liquids of packing group I there must be sufficient inert absorbent to absorb any
spillage, unless the outer packaging is a close fitting moulded plastic box and the substances are not incompatible with the plastic.
Aerosol dispenser.
Check that containers are clearly labelled.
Storage incompatibility
1,1-Difluorethane:
reacts violently with strong oxidisers, barium, sodium and potassium
is incompatible with powdered aluminium, liquid oxygen
may form explosive compounds with divalent light metals and metallic azides
attacks some metals in the presence of moisture
undergoes thermal decomposition when exposed to flame or red-hot surfaces
may generate electrostatic charges due to low conductivity.
Methyl acetate:
reacts violently with oxidisers
decomposes on contact with acid or bases forming methanol
is incompatible with nitrates
attacks some plastics
may generate electrostatic charges
Low molecular weight alkanes:
May react violently with strong oxidisers, chlorine, chlorine dioxide, dioxygenyl tetrafluoroborate.
May react with oxidising materials, nickel carbonyl in the presence of oxygen, heat.
Are incompatible with nitronium tetrafluoroborate(1-), halogens and interhalogens
may generate electrostatic charges, due to low conductivity, on flow or agitation.
Avoid flame and ignition sources
Redox reactions of alkanes, in particular with oxygen and the halogens, are possible as the carbon atoms are in a strongly reduced condition.
Reaction with oxygen (if present in sufficient quantity to satisfy the reaction stoichiometry) leads to combustion without any smoke, producing
carbon dioxide and water. Free radical halogenation reactions occur with halogens, leading to the production of haloalkanes. In addition, alkanes
have been shown to interact with, and bind to, certain transition metal complexes
Interaction between chlorine and ethane over activated carbon at 350 deg C has caused explosions, but added carbon dioxide reduces the risk.
The violent interaction of liquid chlorine injected into ethane at 80 deg C/10 bar becomes very violent if ethylene is also present A mixture
prepared at -196 deg C with either methane or ethane exploded when the temp was raised to -78 deg C. Addition of nickel carbonyl to an
n-butane-oxygen mixture causes an explosion at 20-40 deg C.
Alkanes will react with steam in the presence of a nickel catalyst to give hydrogen.
Butane/ isobutane
reacts violently with strong oxidisers
reacts with acetylene, halogens and nitrous oxides
is incompatible with chlorine dioxide, conc. nitric acid and some plastics
may generate electrostatic charges, due to low conductivity, in flow or when agitated - these may ignite the vapour.
Segregate from nickel carbonyl in the presence of oxygen, heat (20-40 C)
Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidising acids may cause a vigorous reaction with esters that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Esters may be incompatible with aliphatic amines and nitrates.
Propane:
reacts violently with strong oxidisers, barium peroxide, chlorine dioxide, dichlorine oxide, fluorine etc.
liquid attacks some plastics, rubber and coatings
may accumulate static charges which may ignite its vapours
SECTION 8 Exposure controls / personal protection
Control parameters
Occupational Exposure Limits (OEL)
INGREDIENT DATA
US OSHA Permissible Exposure
Limits (PELs) Table Z-1
methyl acetate Methyl acetate 200 ppm / 610 mg/m3 Not Available Not Available Not Available
US NIOSH Recommended
Exposure Limits (RELs)
methyl acetate Methyl acetate 200 ppm / 610 mg/m3 760 mg/m3 / 250 ppm Not Available Not Available
US NIOSH Recommended
Exposure Limits (RELs)
butane n-Butane 800 ppm / 1900 mg/m3 Not Available Not Available Not Available Version No: 7.8 Page 5 of 18
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
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Source Ingredient Material name TWA STEL Peak Notes
Ingredient TEEL-1 TEEL-2 TEEL-3
Ingredient Original IDLH Revised IDLH
Ingredient Occupational Exposure Band Rating Occupational Exposure Band Limit
Notes: Occupational exposure banding is a process of assigning chemicals into specific categories or bands based on a chemical's potency and the
adverse health outcomes associated with exposure. The output of this process is an occupational exposure band (OEB), which corresponds to a
range of exposure concentrations that are expected to protect worker health.
US OSHA Permissible Exposure
Limits (PELs) Table Z-1
propane Propane 1000 ppm / 1800 mg/m3 Not Available Not Available Not Available
US NIOSH Recommended
Exposure Limits (RELs)
propane Propane 1000 ppm / 1800 mg/m3 Not Available Not Available Not Available
US NIOSH Recommended
Exposure Limits (RELs)
iso-butane Isobutane 800 ppm / 1900 mg/m3 Not Available Not Available Not Available
Emergency Limits
methyl acetate 250 ppm 1,700 ppm 10000* ppm
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
1,000 mg/m3 11,000 mg/m3 66,000 mg/m3
butane Not Available Not Available Not Available
propane Not Available Not Available Not Available
iso-butane 5500* ppm 17000** ppm 53000*** ppm
1,1-difluoroethane Not Available Not Available Not Available
methyl acetate 3,100 ppm Not Available
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
Not Available Not Available
butane Not Available 1,600 ppm
propane 2,100 ppm Not Available
iso-butane Not Available Not Available
1,1-difluoroethane Not Available Not Available
Occupational Exposure Banding
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
E 0.1 ppm
1,1-difluoroethane E 0.1 ppm
Exposure controls
Appropriate engineering
controls
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering controls can
be highly effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection.
The basic types of engineering controls are:
Process controls which involve changing the way a job activity or process is done to reduce the risk.
Enclosure and/or isolation of emission source which keeps a selected hazard 'physically' away from the worker and ventilation that strategically
'adds' and 'removes' air in the work environment. Ventilation can remove or dilute an air contaminant if designed properly. The design of a
ventilation system must match the particular process and chemical or contaminant in use.
Employers may need to use multiple types of controls to prevent employee overexposure.
General exhaust is adequate under normal conditions. If risk of overexposure exists, wear SAA approved respirator. Correct fit is essential to
obtain adequate protection.
Provide adequate ventilation in warehouse or closed storage areas.
Air contaminants generated in the workplace possess varying 'escape' velocities which, in turn, determine the 'capture velocities' of fresh
circulating air required to effectively remove the contaminant.
Type of Contaminant: Speed:
aerosols, (released at low velocity into zone of active generation) 0.5-1 m/s
direct spray, spray painting in shallow booths, gas discharge (active generation into zone of rapid air motion)1-2.5 m/s (200-500 f/min.)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to capture1: Disturbing room air currents
2: Contaminants of low toxicity or of nuisance value only.2: Contaminants of high toxicity
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood-local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally decreases
with the square of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should be adjusted,
accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example, should be a minimum of
1-2 m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from the extraction point. Other mechanical
considerations, producing performance deficits within the extraction apparatus, make it essential that theoretical air velocities are multiplied by
factors of 10 or more when extraction systems are installed or used. Version No: 7.8 Page 6 of 18
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Individual protection
measures, such as personal
protective equipment
Eye and face protection
Safety glasses with side shields.
Chemical goggles.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing
the wearing of lenses or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption
and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in
their removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and
remove contact lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in
a clean environment only after workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59], [AS/NZS 1336 or
national equivalent]
Skin protectionSee Hand protection below
Hands/feet protection
For esters:
Do NOT use natural rubber, butyl rubber, EPDM or polystyrene-containing materials.
No special equipment needed when handling small quantities.
OTHERWISE:
For potentially moderate exposures:
Wear general protective gloves, eg. light weight rubber gloves.
For potentially heavy exposures:
Wear chemical protective gloves, eg. PVC. and safety footwear.
Body protection See Other protection below
Other protection
No special equipment needed when handling small quantities.
OTHERWISE:
Overalls.
Skin cleansing cream.
Eyewash unit.
Do not spray on hot surfaces.
Recommended material(s)
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
'Forsberg Clothing Performance Index'.
The effect(s) of the following substance(s) are taken into account in the computer-
generated selection:
METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
BUTYL A
PE/EVAL/PE A
PVA C
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove, a final
selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis, factors such
as 'feel' or convenience (e.g. disposability), may dictate a choice of gloves which might
otherwise be unsuitable following long-term or frequent use. A qualified practitioner
should be consulted.
Material CPI
Respiratory protection
Type AX-P Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001,
ANSI Z88 or national equivalent)
Where the concentration of gas/particulates in the breathing zone, approaches or
exceeds the 'Exposure Standard' (or ES), respiratory protection is required.
Degree of protection varies with both face-piece and Class of filter; the nature of
protection varies with Type of filter.
Required Minimum
Protection Factor
Half-Face
Respirator
Full-Face
Respirator
Powered Air
Respirator
up to 5 x ES
AX-AUS / Class
1 P2
-
AX-PAPR-AUS /
Class 1 P2
up to 25 x ES Air-line* AX-2 P2 AX-PAPR-2 P2
up to 50 x ES - AX-3 P2 -
50+ x ES - Air-line** -
* - Continuous-flow; ** - Continuous-flow or positive pressure demand
^ - Full-face
A(All classes) = Organic vapours, B AUS or B1 = Acid gasses, B2 = Acid gas or
hydrogen cyanide(HCN), B3 = Acid gas or hydrogen cyanide(HCN), E = Sulfur
dioxide(SO2), G = Agricultural chemicals, K = Ammonia(NH3), Hg = Mercury, NO =
Oxides of nitrogen, MB = Methyl bromide, AX = Low boiling point organic
compounds(below 65 degC)
Cartridge respirators should never be used for emergency ingress or in areas of
unknown vapour concentrations or oxygen content.
The wearer must be warned to leave the contaminated area immediately on
detecting any odours through the respirator. The odour may indicate that the mask is
not functioning properly, that the vapour concentration is too high, or that the mask is
not properly fitted. Because of these limitations, only restricted use of cartridge
respirators is considered appropriate.
Cartridge performance is affected by humidity. Cartridges should be changed after 2
hr of continuous use unless it is determined that the humidity is less than 75%, in
which case, cartridges can be used for 4 hr. Used cartridges should be discarded
daily, regardless of the length of time used
Generally not applicable.
Aerosols, in common with most vapours/ mists, should never be used in confined spaces
without adequate ventilation. Aerosols, containing agents designed to enhance or mask
smell, have triggered allergic reactions in predisposed individuals.
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors
(defined as the ratio of contaminant outside and inside the mask) may also be important.
Required
minimum
protection factor
Maximum gas/vapour
concentration present in air
p.p.m. (by volume)
Half-face
Respirator
Full-Face
Respirator
up to 10 1000
AX-AUS /
Class 1
- Version No: 7.8 Page 7 of 18
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up to 50 1000 -
AX-AUS /
Class 1
up to 50 5000 Airline * -
up to 100 5000 - AX-2
up to 100 10000 - AX-3
100+ - Airline**
** - Continuous-flow or positive pressure demand.
A(All classes) = Organic vapours, B AUS or B1 = Acid gases, B2 = Acid gas or hydrogen
cyanide(HCN), B3 = Acid gas or hydrogen cyanide(HCN), E = Sulfur dioxide(SO2), G =
Agricultural chemicals, K = Ammonia(NH3), Hg = Mercury, NO = Oxides of nitrogen, MB
= Methyl bromide, AX = Low boiling point organic compounds(below 65 deg C)
SECTION 9 Physical and chemical properties
Information on basic physical and chemical properties
Appearance Coloured
Physical stateDissolved Gas Relative density (Water = 1)0.87
Odour Not Available
Partition coefficient n-octanol
/ water
Not Available
Odour threshold Not Available Auto-ignition temperature ( C)Not Available
pH (as supplied)Not Available
Decomposition
temperature ( C)
Not Available
Melting point / freezing point
( C)
Not Available Viscosity (cSt)57
Initial boiling point and boiling
range ( C)
>57 Molecular weight (g/mol)Not Available
Flash point ( C)-26 Taste Not Available
Evaporation rateNot Available Explosive propertiesNot Available
Flammability HIGHLY FLAMMABLE. Oxidising propertiesNot Available
Upper Explosive Limit (%)16
Surface Tension (dyn/cm or
mN/m)
Not Available
Lower Explosive Limit (%)1 Volatile Component (%vol) Not Available
Vapour pressure (kPa) Not Available Gas group Not Available
Solubility in waterImmiscible pH as a solution (1%)Not Available
Vapour density (Air = 1)Not Available VOC % 592.99
SECTION 10 Stability and reactivity
ReactivitySee section 7
Chemical stability
Elevated temperatures.
Presence of open flame.
Product is considered stable.
Hazardous polymerisation will not occur.
Possibility of hazardous
reactions
See section 7
Conditions to avoidSee section 7
Incompatible materialsSee section 7
Hazardous decomposition
products
See section 5
SECTION 11 Toxicological information
Information on toxicological effects
Inhaled
The material can cause respiratory irritation in some persons. The body’s response to such irritation can cause further lung damage.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by sleepiness, reduced alertness, loss of reflexes, lack of
co-ordination, and vertigo.
The main effects of simple esters are irritation, stupor and insensibility. Headache, drowsiness, dizziness, coma and behavioural changes may
occur.
Isobutane produces a dose dependent action and at high concentrations may cause numbness, suffocation, exhilaration, dizziness, headache,
nausea, confusion, incoordination and unconsciousness in severe cases. Version No: 7.8 Page 8 of 18
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The paraffin gases are practically not harmful at low doses. Higher doses may produce reversible brain and nerve depression and irritation.
Exposure to methyl acetate fumes may lead to shortness of breath and an irregular heartbeat. Inhalation of methyl acetate causes severe
headache and sleepiness.
Animal testing showed a single, high-level exposure to 1,1-difluoroethane by inhalation has caused difficulty breathing, lung irritation, lethargy,
inco-ordination, and loss of consciousness, with sensitisation of the heart occurring at a concentration of 15% after adrenaline was given into a
vein. Repeated exposure caused increased urinary fluoride, reduced kidney weight and reversible kidney changes. Inhaling high concentrations
can depress the central nervous system, which may lead to inco-ordination, impaired judgment and, if exposure is prolonged, unconsciousness
and even death.
The vapour is discomforting
WARNING:Intentional misuse by concentrating/inhaling contents may be lethal.
Inhaling high concentrations of mixed hydrocarbons can cause narcosis, with nausea, vomiting and lightheadedness. Low molecular weight
(C2-C12) hydrocarbons can irritate mucous membranes and cause incoordination, giddiness, nausea, vertigo, confusion, headache, appetite
loss, drowsiness, tremors and stupor.
Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic
effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and
may be fatal.
Nerve damage can be caused by some non-ring hydrocarbons. Symptoms are temporary, and include weakness, tremors, increased saliva,
some convulsions, excessive tears with discolouration and inco-ordination lasting up to 24 hours.
Inhalation of high concentrations of gas/vapour causes lung irritation with coughing and nausea, central nervous depression with headache and
dizziness, slowing of reflexes, fatigue and inco-ordination.
Material is highly volatile and may quickly form a concentrated atmosphere in confined or unventilated areas. The vapour may displace and
replace air in breathing zone, acting as a simple asphyxiant. This may happen with little warning of overexposure.
The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing.
Before starting consider control of exposure by mechanical ventilation.
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health
of the individual.
Ingestion
Methanol may produce a burning or painful sensation in the mouth, throat, chest, and stomach. This may be accompanied by nausea, vomiting,
headache, dizziness, shortness of breath, weakness, fatigue, leg cramps, restlessness, confusion, drunken behaviour, visual disturbance,
drowsiness, coma and death.
Swallowing large doses of methyl acetate may result in severe cramping, intoxication and depression of the central nervous system.
A single high oral dose of 1,1-difluoroethane produced weight loss and lethargy.
The material has NOT been classified by EC Directives or other classification systems as ‘harmful by ingestion’. This is because of the lack of
corroborating animal or human evidence.
Isoparaffinic hydrocarbons cause temporary lethargy, weakness, inco-ordination and diarrhoea.
Not normally a hazard due to physical form of product.
Considered an unlikely route of entry in commercial/industrial environments
Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis; serious consequences may result.
(ICSC13733)
Considered an unlikely route of entry in commercial/industrial environments. The liquid may produce gastrointestinal discomfort and may be
harmful if swallowed.
Accidental ingestion of the material may be damaging to the health of the individual.
Skin Contact
The material may accentuate any pre-existing dermatitis condition
Skin contact is not thought to have harmful health effects (as classified under EC Directives); the material may still produce health damage
following entry through wounds, lesions or abrasions.
Skin exposure to isoparaffins may produce slight to moderate irritation in animals and humans. Rare sensitisation reactions in humans have
occurred.
Methyl acetate has proven to cause only weak skin irritation in humans and in rabbits (no oedema, erythema with maximum grade 1 reversible
within 48 hours).
Spray mist may produce discomfort
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin
prior to the use of the material and ensure that any external damage is suitably protected.
There is some evidence to suggest that the material may cause moderate inflammation of the skin either following direct contact or after a delay
of some time. Repeated exposure can cause contact dermatitis which is characterised by redness, swelling and blistering.
Eye
Instillation of isoparaffins into rabbit eyes produces only slight irritation.
Overexposure to methyl acetate vapour may result in a condition known as amylopia (dimming of vision) due to withering of the optic nerve.
Methyl acetate may resemble methanol in this respect. Animal testing showed that methyl acetate causes severe eye irritation, but this is
reversible after exposure ends.
This material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Moderate inflammation
may be expected with redness; conjunctivitis may occur with prolonged exposure.
Chronic
Long-term exposure to respiratory irritants may result in airways disease, involving difficulty breathing and related whole-body problems.
Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.
This material can cause serious damage if one is exposed to it for long periods. It can be assumed that it contains a substance which can
produce severe defects.
Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure.
Constant or exposure over long periods to mixed hydrocarbons may produce stupor with dizziness, weakness and visual disturbance, weight loss
and anaemia, and reduced liver and kidney function. Skin exposure may result in drying and cracking and redness of the skin.
Chronic effects of exposure to methyl acetate may be similar to those of methanol exposure, because methyl acetate can break down in water to
form methanol and acetic acid. The main hazard is damage to the optic nerve.
Long-term exposure to methanol vapour, at concentrations exceeding 3000 ppm, may produce cumulative effects characterised by
gastrointestinal disturbances (nausea, vomiting), headache, ringing in the ears, insomnia, trembling, unsteady gait, vertigo, conjunctivitis and
clouded or double vision. Liver and/or kidney injury may also result.
Prolonged or repeated skin contact may cause drying with cracking, irritation and possible dermatitis following.
METYFIX 3 SPRAY ADHESIVE
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SPRAY ADHESIVE
TOXICITY IRRITATION
Not Available Not Available Version No: 7.8 Page 9 of 18
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methyl acetate
TOXICITY IRRITATION
dermal (rat) LD50: >2000 mg/kg
[2] Eye (rabbit):100 mg/24h-moderate
Oral (Rabbit) LD50; 3700 mg/kg
[2] Skin (rabbit): 20 mg/24h – mild
Skin (rabbit): 500 mg/24h – mild
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
TOXICITY IRRITATION
Dermal (rabbit) LD50: >1900 mg/kg
[1]
Eye: no adverse effect observed (not irritating)
[1]
Inhalation(Rat) LC50: >4.42 mg/L4h
[1]
Skin: adverse effect observed (irritating)
[1]
Oral (Rat) LD50: >2000 mg/kg
[1]
butane
TOXICITY IRRITATION
Inhalation(Rat) LC50: 658 mg/l4h
[2] Not Available
propane
TOXICITY IRRITATION
Inhalation(Rat) LC50: 364726.819 ppm4h
[2] Not Available
iso-butane
TOXICITY IRRITATION
Inhalation(Rat) LC50: >13023 ppm4h
[1] Not Available
1,1-difluoroethane
TOXICITY IRRITATION
Inhalation(Rat) LC50: >437500 ppm4h
[1] Not Available
Oral (Rat) LD50: 484 mg/kg
[2]
Legend: 1. Value obtained from Europe ECHA Registered Substances – Acute toxicity 2. Value obtained from manufacturer’s SDS. Unless otherwise
specified data extracted from RTECS – Register of Toxic Effect of chemical Substances
METYFIX 3 SPRAY ADHESIVE
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SPRAY ADHESIVE
Asthma-like symptoms may continue for months or even years after exposure to the material ends. This may be due to a non-allergic condition
known as reactive airways dysfunction syndrome (RADS) which can occur after exposure to high levels of highly irritating compound. Main
criteria for diagnosing RADS include the absence of previous airways disease in a non-atopic individual, with sudden onset of persistent
asthma-like symptoms within minutes to hours of a documented exposure to the irritant. Other criteria for diagnosis of RADS include a reversible
airflow pattern on lung function tests, moderate to severe bronchial hyperreactivity on methacholine challenge testing, and the lack of minimal
lymphocytic inflammation, without eosinophilia. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to
the concentration of and duration of exposure to the irritating substance. On the other hand, industrial bronchitis is a disorder that occurs as a
result of exposure due to high concentrations of irritating substance (often particles) and is completely reversible after exposure ceases. The
disorder is characterized by difficulty breathing, cough and mucus production.
Disinfection byproducts (DBPs) are formed when disinfectants such as chlorine, chloramines and ozone react with organic and inorganic matter
in water. Animal studies have shown that some DBPs cause cancer. To date, several hundred DBPs have been identified.
Numerous haloalkanes and haloalkenes have been tested for cancer-causing and mutation-causing activities. In general, the potential to cause
genetic toxicity is dependent on the nature, number and position of halogen(s) and the size of the molecule.
Haloalkenes are of concern because of the potential to generate genetically toxic intermediates after epoxidation. The concern for haloalkenes
may be diminished if the double bond is internal or sterically hindered.
The cancer concern levels of the 14 haloalkenes and haloalkanes, have been rated, based on available screening cancer bioassays and data on
genetic toxicity. Some individuals may be genetically more susceptible to brominated THMs than others.
Six, two and one haloalkanes/haloalkenes have been given low-moderate, marginal and low concern, respectively.
Generally,linear and branched-chain alkyl esters are hydrolysed to their component alcohols and carboxylic acids in the intestinal tract, blood and
most tissues throughout the body. Following hydrolysis the component alcohols and carboxylic acids are metabolized
Oral acute toxicity studies have been reported for 51 of the 67 esters of aliphatic acyclic primary alcohols and aliphatic linear saturated carboxylic
acids. The very low oral acute toxicity of this group of esters is demonstrated by oral LD50 values greater than 1850 mg/kg bw
Genotoxicity studies have been performed in vitro using the following esters of aliphatic acyclic primary alcohols and aliphatic linear saturated
carboxylic acids: methyl acetate, butyl acetate, butyl stearate and the structurally related isoamyl formate and demonstrates that these
substances are not genotoxic.
The JEFCA Committee concluded that the substances in this group would not present safety concerns at the current levels of intake the esters of
aliphatic acyclic primary alcohols and aliphatic linear saturated carboxylic acids are generally used as flavouring substances up to average
maximum levels of 200 mg/kg. Higher levels of use (up to 3000 mg/kg) are permitted in food categories such as chewing gum and hard candy. In
Europe the upper use levels for these flavouring substances are generally 1 to 30 mg/kg foods and in special food categories like candy and
alcoholic beverages up to 300 mg/kg foods
Internationl Program on Chemical Safety: the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Esters of Aliphatic acyclic primary alcohols with aliphatic linear saturated carboxylic acids.; 1998
METHYL ACETATE
The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce
conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of
vesicles, scaling and thickening of the skin.
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
For Low Boiling Point Naphthas (LBPNs):
Acute toxicity:
LBPNs generally have low acute toxicity by the oral (median lethal dose [LD50] in rats > 2000 mg/kg-bw), inhalation (LD50 in rats > 5000 mg/m3)
and dermal (LD50 in rabbits > 2000 mg/kg-bw) routes of exposure
Most LBPNs are mild to moderate eye and skin irritants in rabbits, with the exception of heavy catalytic cracked and heavy catalytic reformed
naphthas, which have higher primary skin irritation indices.
Sensitisation:
LBPNs do not appear to be skin sensitizers, but a poor response in the positive control was also noted in these studies Version No: 7.8 Page 10 of 18
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Repeat dose toxicity:
The lowest-observed-adverse-effect concentration (LOAEC) and lowest-observed-adverse-effect level (LOAEL) values identified following
short-term (2-89 days) and subchronic (greater than 90 days) exposure to the LBPN substances. These values were determined for a variety of
endpoints after considering the toxicity data for all LBPNs in the group. Most of the studies were carried out by the inhalation route of exposure.
Renal effects, including increased kidney weight, renal lesions (renal tubule dilation, necrosis) and hyaline droplet formation, observed in male
rats exposed orally or by inhalation to most LBPNs, were considered species- and sex-specific These effects were determined to be due to a
mechanism of action not relevant to humans -specifically, the interaction between hydrocarbon metabolites and alpha-2-microglobulin, an
enzyme not produced in substantial amounts in female rats, mice and other species, including humans. The resulting nephrotoxicity and
subsequent carcinogenesis in male rats were therefore not considered in deriving LOAEC/LOAEL values.
Only a limited number of studies of short-term and subchronic duration were identified for site-restricted LBPNs. The lowest LOAEC identified in
these studies, via the inhalation route, is 5475 mg/m3, based on a concentration-related increase in liver weight in both male and female rats
following a 13-week exposure to light catalytic cracked naphtha. Shorter exposures of rats to this test substance resulted in nasal irritation at
9041 mg/m3
No systemic toxicity was reported following dermal exposure to light catalytic cracked naphtha, but skin irritation and accompanying
histopathological changes were increased, in a dose-dependent manner, at doses as low as 30 mg/kg-bw per day when applied 5 days per week
for 90 days in rats
No non-cancer chronic toxicity studies (= 1 year) were identified for site-restricted LBPNs and very few non-cancer chronic toxicity studies were
identified for other LBPNs. An LOAEC of 200 mg/m3 was noted in a chronic inhalation study that exposed mice and rats to unleaded gasoline
(containing 2% benzene). This inhalation LOAEC was based on ocular discharge and ocular irritation in rats. At the higher concentration of 6170
mg/m3, increased kidney weight was observed in male and female rats (increased kidney weight was also observed in males only at 870
mg/m3). Furthermore, decreased body weight in male and female mice was also observed at 6170 mg/m3
A LOAEL of 714 mg/kg-bw was identified for dermal exposure based on local skin effects (inflammatory and degenerative skin changes) in mice
following application of naphtha for 105 weeks. No systemic toxicity was reported.
Genotoxicity:
Although few genotoxicity studies were identified for the site-restricted LBPNs, the genotoxicity of several other LBPN substances has been
evaluated using a variety of in vivo and in vitro assays. While in vivo genotoxicity assays were negative overall, the in vitro tests exhibited mixed
results.
For in vivo genotoxicity tests, LBPNs exhibited negative results for chromosomal aberrations and micronuclei induction, but exhibited positive
results in one sister chromatid exchange assay although this result was not considered definitive for clastogenic activity as no genetic material
was unbalanced or lost. Mixtures that were tested, which included a number of light naphthas, displayed mixed results (i.e., both positive and
negative for the same assay) for chromosomal aberrations and negative results for the dominant lethal mutation assay. Unleaded gasoline
(containing 2% benzene) was tested for its ability to induce unscheduled deoxyribonucleic acid (DNA) synthesis (UDS) and replicative DNA
synthesis (RDS) in rodent hepatocytes and kidney cells. UDS and RDS were induced in mouse hepatocytes via oral exposure and RDS was
induced in rat kidney cells via oral and inhalation exposure. Unleaded gasoline (benzene content not stated) exhibited negative results for
chromosomal aberrations and the dominant lethal mutation assay and mixed results for atypical cell foci in rodent renal and hepatic cells.
For in vitro genotoxicity studies, LBPNs were negative for six out of seven Ames tests, and were also negative for UDS and for forward mutations
LBPNs exhibited mixed or equivocal results for the mouse lymphoma and sister chromatid exchange assays, as well as for cell transformation
and positive results for one bacterial DNA repair assay. Mixtures that were tested, which included a number of light naphthas, displayed negative
results for the Ames and mouse lymphoma assays Gasoline exhibited negative results for the Ames test battery, the sister chromatid exchange
assay and for one mutagenicity assay . Mixed results were observed for UDS and the mouse lymphoma assay.
While the majority of in vivo genotoxicity results for LBPN substances are negative, the potential for genotoxicity of LBPNs as a group cannot be
discounted based on the mixed in vitro genotoxicity results.
Carcinogenicity:
Although a number of epidemiological studies have reported increases in the incidence of a variety of cancers, the majority of these studies are
considered to contain incomplete or inadequate information. Limited data, however, are available for skin cancer and leukemia incidence, as well
as mortality among petroleum refinery workers. It was concluded that there is limited evidence supporting the view that working in petroleum
refineries entails a carcinogenic risk (Group 2A carcinogen). IARC (1989a) also classified gasoline as a Group 2B carcinogen; it considered the
evidence for carcinogenicity in humans from gasoline to be inadequate and noted that published epidemiological studies had several limitations,
including a lack of exposure data and the fact that it was not possible to separate the effects of combustion products from those of gasoline itself.
Similar conclusions were drawn from other reviews of epidemiological studies for gasoline (US EPA 1987a, 1987b). Thus, the evidence gathered
from these epidemiological studies is considered to be inadequate to conclude on the effect
s of human exposure to LBPN substances.
No inhalation studies assessing the carcinogenicity of the site-restricted LBPNs were identified. Only unleaded gasoline has been examined for
its carcinogenic potential, in several inhalation studies. In one study, rats and mice were exposed to 0, 200, 870 or 6170 mg/m3 of a 2% benzene
formulation of the test substance, via inhalation, for approximately 2 years. A statistically significant increase in hepatocellular adenomas and
carcinomas, as well as a non-statistical increase in renal tumours, were observed at the highest dose in female mice. A dose-dependent increase
in the incidence of primary renal neoplasms was also detected in male rats, but this was not considered to be relevant to humans, as discussed
previously.Carcinogenicity was also assessed for unleaded gasoline, via inhalation, as part of initiation/promotion studies. In these studies,
unleaded gasoline did not appear to initiate tumour formation, but did show renal cell and hepatic tumour promotion ability, when rats and mice
were exposed, via inhalation, for durations ranging from 13 weeks to approximately 1 year using an initiation/promotion protocol However, further
examination of data relevant to the composition of unleaded gasoline demonstrated that this is a highly-regulated substance; it is expected to
contain a lower percentage of benzene and has a discrete component profile when compared to other substances in the LBPN group.
Both the European Commission and the International Agency for Research on Cancer (IARC) have classified LBPN substances as carcinogenic.
All of these substances were classified by the European Commission (2008) as Category 2 (R45: may cause cancer) (benzene content = 0.1%
by weight). IARC has classified gasoline, an LBPN, as a Group 2B carcinogen (possibly carcinogenic to humans) and occupational exposures in
petroleum refining as Group 2A carcinogens (probably carcinogenic to humans).
Several studies were conducted on experimental animals to investigate the dermal carcinogenicity of LBPNs. The majority of these studies were
conducted through exposure of mice to doses ranging from 694-1351 mg/kg-bw, for durations ranging from 1 year to the animals lifetime or until
a tumour persisted for 2 weeks. Given the route of exposure, the studies specifically examined the formation of skin tumours. Results for
carcinogenicity via dermal exposure are mixed. Both malignant and benign skin tumours were induced with heavy catalytic cracked naphtha, light
catalytic cracked naphtha, light
straight-run naphtha and naphtha Significant increases in squamous cell carcinomas were also observed when mice were dermally treated with
Stoddard solvent, but the latter was administered as a mixture (90% test substance), and the details of the study were not available. In contrast,
insignificant increases in tumour formation or no tumours were observed when light alkylate naphtha, heavy catalytic reformed naphtha,
sweetened naphtha, light catalytically cracked naphtha
or unleaded gasoline was dermally applied to mice. Negative results for skin tumours were also observed in male mice dermally exposed to
sweetened naphtha using an initiation/promotion protocol.
Reproductive/ Developmental toxicity:
No reproductive or developmental toxicity was observed for the majority of LBPN substances evaluated. Most of these studies were carried out
by inhalation exposure in rodents.
NOAEC values for reproductive toxicity following inhalation exposure ranged from 1701 mg/m3 (CAS RN 8052-41-3) to 27 687 mg/m3 (CAS RN
64741-63-5) for the LBPNs group evaluated, and from 7690 mg/m3 to 27 059 mg/m3 for the site-restricted light catalytic cracked and full-range
catalytic reformed naphthas. However, a decreased number of pups per litter and higher frequency of post-implantation loss were observed
following inhalation exposure of female rats to hydrotreated heavy naphtha (CAS RN 64742-48-9) at a concentration of 4679 mg/m3, 6 hours per
day, from gestational days 7-20. For dermal exposures, NOAEL values of 714 mg/kg-bw (CAS RN 8030-30-6) and 1000 mg/kg-bw per day (CAS
RN 68513-02-0) were noted . For oral exposures, no adverse effects on reproductive parameters were reported when rats were given
site-restricted light catalytic cracked naphtha at 2000 mg/kg on gestational day 13 .
For most LBPNs, no treatment-related developmental effects were observed by the different routes of exposure However, developmental toxicity Version No: 7.8 Page 11 of 18
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was observed for a few naphthas. Decreased foetal body weight and an increased incidence of ossification variations were observed when rat
dams were exposed to light aromatized solvent naphtha, by gavage, at 1250 mg/kg-bw per day. In addition, pregnant rats exposed by inhalation
to hydrotreated heavy naphtha at 4679 mg/m3 delivered pups with higher birth weights. Cognitive and memory impairments were also observed
in the offspring.
Low Boiling Point Naphthas [Site-Restricted]
For petroleum: This product contains benzene, which can cause acute myeloid leukaemia, and n-hexane, which can be metabolized to
compounds which are toxic to the nervous system. This product contains toluene, and animal studies suggest high concentrations of toluene lead
to hearing loss. This product contains ethyl benzene and naphthalene, from which animal testing shows evidence of tumour formation.
Cancer-causing potential: Animal testing shows inhaling petroleum causes tumours of the liver and kidney; these are however not considered to
be relevant in humans.
Mutation-causing potential: Most studies involving gasoline have returned negative results regarding the potential to cause mutations, including
all recent studies in living human subjects (such as in petrol service station attendants).
Reproductive toxicity: Animal studies show that high concentrations of toluene (>0.1%) can cause developmental effects such as lower birth
weight and developmental toxicity to the nervous system of the foetus. Other studies show no adverse effects on the foetus.
Human effects: Prolonged or repeated contact may cause defatting of the skin which can lead to skin inflammation and may make the skin more
susceptible to irritation and penetration by other materials.
Animal testing shows that exposure to gasoline over a lifetime can cause kidney cancer, but the relevance in humans is questionable.
PROPANE No significant acute toxicological data identified in literature search.
1,1-DIFLUOROETHANE
1,1-difluoroethane is practically non-toxic following acute or chronic inhalation exposure. In animal testing, extremely high concentrations (5%
and over) may cause reduced contraction of heart muscle and at even higher levels, heartbeat irregularities. It seems to have a weak effect in
damaging genetic material in cells. Studies have not shown it to cause developmental or reproductive toxicity, and it has not been shown to
cause mutations.
METYFIX 3 SPRAY ADHESIVE
AEROSOL, MULTI-PURPOSE
SPRAY ADHESIVE &
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
Animal studies indicate that normal, branched and cyclic paraffins are absorbed from the gastrointestinal tract and that the absorption of
n-paraffins is inversely proportional to the carbon chain length, with little absorption above C30. With respect to the carbon chain lengths likely to
be present in mineral oil, n-paraffins may be absorbed to a greater extent than iso- or cyclo-paraffins.
The major classes of hydrocarbons are well absorbed into the gastrointestinal tract in various species. In many cases, the hydrophobic
hydrocarbons are ingested in association with fats in the diet. Some hydrocarbons may appear unchanged as in the lipoprotein particles in the
gut lymph, but most hydrocarbons partly separate from fats and undergo metabolism in the gut cell. The gut cell may play a major role in
determining the proportion of hydrocarbon that becomes available to be deposited unchanged in peripheral tissues such as in the body fat stores
or the liver.
METYFIX 3 SPRAY ADHESIVE
AEROSOL, MULTI-PURPOSE
SPRAY ADHESIVE & METHYL
ACETATE
For methyl acetate:
Acute toxicity: Methyl acetate is a water-soluble substance with high volatility. In animal testing, the substance has narcotic properties at high
concentration; this is soon reversible after exposure ends.
Methyl acetate is absorbed via the lungs. After absorption, it is broken down to methanol and acetic acid. The main breakdown product is
methanol, which is itself metabolized to formic acid. Methanol is highly toxic, so methyl acetate is of concern for acute toxicity. In humans,
accidental inhalation of vapours of methyl acetate caused severe headache and considerable sleepiness. Methyl acetate has proven to cause
only weak skin irritation in humans. Eye irritation, however, was severe, but in animal testing was reversible after 7 days. Exposure to methyl
acetate vapours causes irritation to the eyes and airways.
Sensitisation: Methyl acetate is not expected to sensitise the skin.
Repeat dose toxicity: Adequate data does not exist for repeated or prolonged exposure in humans. Methyl acetate may cause dryness and
cracking of the skin.
Mutation-causing potential: In testing involving bacterial and animal cells, methyl acetate had negative results. Furthermore, the breakdown
products, methanol and acetic acid, show no evidence for causing mutations. Methyl acetate should not be classified as causing mutations.
Reproductive toxicity: There is no data on the reproductive toxicity of methyl acetate. Methanol, one of the breakdown products, showed some
toxicity to the foetus and potential for birth defects, but at high concentrations only, which were toxic to the mother.
Acute Toxicity
Carcinogenicity
Skin Irritation/Corrosion Reproductivity
Serious Eye Damage/Irritation STOT - Single Exposure
Respiratory or Skin
sensitisation
STOT - Repeated Exposure
Mutagenicity Aspiration Hazard
Legend: Data either not available or does not fill the criteria for classification
Data available to make classification
SECTION 12 Ecological information
Toxicity
METYFIX 3 SPRAY ADHESIVE
AEROSOL, MULTI-PURPOSE
SPRAY ADHESIVE
Endpoint Test Duration (hr) Species Value Source
Not Available Not Available Not Available Not Available Not Available
methyl acetate
Endpoint Test Duration (hr) Species Value Source
NOEC(ECx) 72h Algae or other aquatic plants >=120mg/l 1
EC50 72h Algae or other aquatic plants >120mg/l 1
LC50 96h Fish 250mg/l 1
EC50 48h Crustacea 1026.7mg/l 1
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
Endpoint Test Duration (hr) Species Value Source
NOEC(ECx) 504h Crustacea 0.17mg/l 2
LC50 96h Fish 4.26mg/l 2
EC50 96h Algae or other aquatic plants 64mg/l 2
EC50 48h Crustacea 0.64mg/l 2 Version No: 7.8 Page 12 of 18
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butane
Endpoint Test Duration (hr) Species Value Source
LC50 96h Fish 24.11mg/l 2
EC50(ECx) 96h Algae or other aquatic plants 7.71mg/l 2
EC50 96h Algae or other aquatic plants 7.71mg/l 2
propane
Endpoint Test Duration (hr) Species Value Source
Not Available Not Available Not Available Not Available Not Available
iso-butane
Endpoint Test Duration (hr) Species Value Source
EC50(ECx) 96h Algae or other aquatic plants 7.71mg/l 2
EC50 96h Algae or other aquatic plants 7.71mg/l 2
LC50 96h Fish 24.11mg/l 2
1,1-difluoroethane
Endpoint Test Duration (hr) Species Value Source
EC50(ECx) 96h Algae or other aquatic plants 47.755mg/l 2
EC50 96h Algae or other aquatic plants 47.755mg/l 2
LC50 96h Fish 291.31mg/l 2
EC50 48h Crustacea 146.695mg/l 2
Legend: Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 4. US EPA,
Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan)
- Bioconcentration Data 8. Vendor Data
Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Do NOT allow product to come in contact with surface waters or to intertidal areas below the mean high water mark. Do not contaminate water when cleaning equipment or disposing
of equipment wash-waters.
Wastes resulting from use of the product must be disposed of on site or at approved waste sites.
When released in the environment, alkanes don't undergo rapid biodegradation, because they have no functional groups (like hydroxyl or carbonyl) that are needed by most
organisms in order to metabolize the compound.
However, some bacteria can metabolise some alkanes (especially those linear and short), by oxidizing the terminal carbon atom. The product is an alcohol, that could be next oxidised
to an aldehyde, and finally to a carboxylic acid. The resulting fatty acid could be metabolised through the fatty acid degradation pathway.
For petroleum distillates:
Environmental fate:
When petroleum substances are released into the environment, four major fate processes will take place: dissolution in water, volatilization, biodegradation and adsorption. These
processes will cause changes in the composition of these UVCB substances. In the case of spills on land or water surfaces, photodegradation-another fate process-can also be
significant.
As noted previously, the solubility and vapour pressure of components within a mixture will differ from those of the component alone. These interactions are complex for complex
UVCBs such as petroleum hydrocarbons.
Each of the fate processes affects hydrocarbon families differently. Aromatics tend to be more water-soluble than aliphatics of the same carbon number, whereas aliphatics tend to be
more volatile. Thus,when a petroleum mixture is released into the environment, the principal water contaminants are likely to be aromatics, whereas aliphatics will be the principal air
contaminants . The trend in volatility by component class is as follows: alkenes = alkanes > aromatics = cycloalkanes.
The most soluble and volatile components have the lowest molecular weight; thus there is a general shift to higher molecular weight components in residual materials.
Biodegradation:
Biodegradation is almost always operative when petroleum mixtures are released into the environment. It has been widely demonstrated that nearly all soils and sediments have
populations of bacteria and other organisms capable of degrading petroleum hydrocarbons Degradation occurs both in the presence and absence of oxygen. Two key factors that
determine degradation rates are oxygen supply and molecular structure. In general, degradation is more rapid under aerobic conditions. Decreasing trends in degradation rates
according to structure are as follows:
(1) n-alkanes, especially in the C10 C25 range, which are degraded readily;
(2) isoalkanes;
(3) alkenes;
(4) benzene, toluene, ethylbenzene, xylenes (BTEX) (when present in concentrations that are not toxic to microorganisms);
(5) monoaromatics;
(6) polynuclear (polycyclic) aromatic hydrocarbons (PAHs); and
(7) higher molecular weight cycloalkanes (which may degrade very slowly.
Three weathering processes-dissolution in water, volatilization and biodegradation-typically result in the depletion of the more readily soluble,volatile and degradable compounds and
the accumulation of those most resistant to these processes in residues.
When large quantities of a hydrocarbon mixture enter the soil compartment, soil organic matter and other sorption sites in soil are fully saturated and the hydrocarbons will begin to
form a separate phase (a non-aqueous phase liquid, or NAPL) in the soil. At concentrations below the retention capacity for the hydrocarbon in the soil, the NAPL will be immobile this
is referred to as residual NAPL . Above the retention capacity, the NAPL becomes mobile and will move within the soil
Bioaccumulation:
Bioaccumulation potential was characterized based on empirical and/or modelled data for a suite of petroleum hydrocarbons expected to occur in petroleum substances.
Bioaccumulation factors (BAFs) are the preferred metric for assessing the bioaccumulation potential of substances, as the bioconcentration factor (BCF) may not adequately account
for the bioaccumulation potential of substances via the diet, which predominates for substances with log Kow > ~4.5
In addition to fish BCF and BAF data, bioaccumulation data for aquatic invertebrate species were also considered. Biota-sediment/soil accumulation factors (BSAFs), trophic
magnification factors and biomagnification factors were also considered in characterizing bioaccumulation potential.
Overall, there is consistent empirical and predicted evidence to suggest that the following components have the potential for high bioaccumulation, with BAF/BCF values greater than
5000: C13 C15 isoalkanes, C12 alkenes, C12 C15 one-ring cycloalkanes, C12 and C15 two-ring cycloalkanes, C14 polycycloalkanes, C15 one-ring aromatics, C15 and C20
cycloalkane monoaromatics, C12 C13 diaromatics, C20 cycloalkane diaromatics, and C14 and C20 three-ring PAHs
These components are associated with a slow rate of metabolism and are highly lipophilic. Exposures from water and diet, when combined, suggest that the rate of uptake would
exceed that of the total elimination rate. Most of these components are not expected to biomagnify in aquatic or terrestrial foodwebs, largely because a combination of metabolism, low
dietary assimilation efficiency and growth dilution allows the elimination rate to exceed the uptake rate from the diet; however,
one study suggests that some alkyl-PAHs may biomagnify.While only BSAFs were found for some PAHs, it is possible that BSAFs will be > 1 for invertebrates, given that they do not
have the same metabolic competency as fish.
In general, fish can efficiently metabolize aromatic compounds. There is some evidence that alkylation increases bioaccumulation of naphthalene but it is not known if this can be
generalized to larger PAHs or if any potential increase in bioaccumulation due to alkylation will be sufficient to exceed a BAF/BCF of 5000.
Some lower trophic level organisms (i.e., invertebrates) appear to lack the capacity to efficiently metabolize aromatic compounds, resulting in high bioaccumulation potential for some
aromatic components as compared to fish. Version No: 7.8 Page 13 of 18
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This is the case for the C14 three-ring PAH, which was bioconcentrated to a high level (BCF > 5000) by invertebrates but not by fish. There is potential for such bioaccumulative
components to reach toxic levels in organisms if exposure is continuous and of sufficient magnitude, though this is unlikely in the water column following a spill scenario due to
relatively rapid dispersal
Bioaccumulation of aromatic compounds might be lower in natural environments than what is observed in the laboratory. PAHs may sorb to organic material suspended in the water
column (dissolved humic material), which decreases their overall bioavailability primarily due to an increase in size. This has been observed with fish
Ecotoxicity:
Diesel fuel studies in salt water are available. The values varied greatly for aquatic species such as rainbow trout and Daphnia magna, demonstrating the inherent variability of diesel
fuel compositions and its effects on toxicity. Most experimental acute toxicity values are above 1 mg/L. The lowest 48-hour LC50 for salmonids was 2.4 mg/L. Daphnia magna had a
24-hour LC50 of 1.8 mg/.The values varied greatly for aquatic species such as rainbow trout and Daphnia magna, demonstrating the inherent variability of diesel fuel compositions
and its effects on toxicity. Most experimental acute toxicity values are above 1 mg/L. The lowest 48-hour LC50 for salmonids was 2.4 mg/L. Daphnia magna had a 24-hour LC50 of 1.8
mg/L
The tropical mysid Metamysidopsis insularis was shown to be very sensitive to diesel fuel, with a 96-hour LC50 value of 0.22 mg/L this species has been shown to be as sensitive as
temperate mysids to toxicants. However,However this study used nominal concentrations,and therefore was not considered acceptable. In another study involving diesel fuel, the
effect on brown or common shrimp (Crangon crangon) a 96-hour LC50 of 22 mg/L was determined. A gas oil was also tested and a 96-hour LC50 of 12 mg/L.was determined
The steady state cell density of marine phytoplankton decreased with increasing concentrations of diesel fuel, with different sensitivities between species . The diatom Phaeodactylum
tricornutum showed a 20% decrease in cell density in 24 hours following a 3 mg/L exposure with a 24-hour no-observed effect concentration (NOEC) of 2.5 mg/L. The microalga
Isochrysis galbana was more tolerant to diesel fuel, with a 24-hour lowest-observed-effect concentration (LOEC) of 26 mg/L (14% decrease in cell density), and a NOEC of 25 mg/L.
Finally, the green algae Chlorella salina was relatively insensitive to diesel fuel contamination, with a 24-hour LOEC of 170 mg/L (27% decrease in cell density), and a NOEC of 160
mg/L . All populations of phytoplankton returned to a steady state within 5 days of exposure
In sandy soils, earthworm (Eisenia fetida) mortality only occurred at diesel fuel concentrations greater than 10 000 mg/kg, which was also the concentration at which sub-lethal weight
loss was recorded
Nephrotoxic effects of diesel fuel have been documented in several animal and human studies.Some species of birds (mallard ducks in particular) are generally resistant to the toxic
effects of petrochemical ingestion, and large amounts of petrochemicals are needed in order to cause direct mortality
For 1,1-Difluorethane: Log Kow: 0.75; BCF: 2.
Environmental Fate: 1,1-difluoroethane is expected to exist solely as a vapor in the ambient atmosphere with a half-life of about 472 days. Some 1,1-difluoroethane is expected to
diffuse into the stratosphere above the ozone layer where it will slowly degrade due to direct photolysis from UV-radiation.
Aquatic Fate: The estimated half-life for a model river is 2 hours and model lake is 77 hours. 1,1-Difluoroethane is not expected to adsorb to suspended solids and sediment. The
chemical is expected to volatilize rapidly from surface water.
Atmospheric Fate: Ninety-nine percent of 1,1-difluorethane released to air distributes to the atmospheric compartment.
Ecotoxicity: 1,1-difluoroethane is unlikely to represent an unacceptable risk to aquatic organisms or wildlife. Bioconcentration of this chemical tends to be low and is slightly to
relatively non-toxic to fish and Daphnia magna water fleas. The substance is moderately toxic to algae.
for methyl actetate:
Environmental fate:
Biodegradation
The substance can be classified as readily biodegradable on the basis of an available study according to OECD-guideline 301 D. This closed bottle test indicates 74%
biodegradation after 14 days, 75% after 19 days and 70% after 28 days. There is no information on possible intermediates before ultimate degradation of methyl acetate. Probably
methanol and acetic acid could be intermediates of the biodegradation. The degradation of the possible intermediates is included in the results of the biodegradation test.
Photodegradation
Direct photolysis of methyl acetate in the atmosphere is not to be expected. However, in the atmosphere gaseous methyl acetate reacts with hydroxyl radicals which have been
formed photochemically. On the basis of an atmospheric concentration of the OH-radicals amounting to 5.10exp5 OH/cm3 and the rate constant (kdeg(air)) of 0.3182.10exp-
12cm3.molecule-1.s-1, a half-life of 50.4 days is calculated for the photochemical degradation in the atmosphere. A half-life of 94 days was determined on the basis of laboratory
investigations into photochemical degradation.
Hydrolysis
The hydrolysis of methyl acetate was examined in an older investigation from 1935. In this, a hydrolysis half-life of approximately 53 days at a temperature of 23.2 to 25.4 deg C was
determined for methyl acetate (148.6 g/l). No information was provided on the pH value of the solution.
Hydrolysis half-lives of between approximately 63 days (pH = 8) and approximately 627 days (pH = 7) were calculated for the substance using QSAR calculations. Hydrolysis should
therefore not represent a significant elimination process for methyl acetate in the environment.
Distribution
On account of the vapour pressure of 217 hPa, methyl acetate is expected to evaporate quickly from surfaces.
A Henrys Constant of 6.43 Pa m3/mol at 20 deg C is calculated from the data on the vapour pressure and water solubility of methyl acetate given in Section 1. Consequently, the
substance is moderately volatile from an aqueous solution..
No bioaccumulation potential is to be expected due to the measured log Kow value for methyl acetate of 0.18. On the basis of this value the Koc is calculated as 12.99 l/kg and the
partition coefficients can be calculated according to the organic carbon content in the individual environmental compartments.
Accumulation
No investigations on bioaccumulation are available. The measured log Kow of 0.18 does not provide any indication of a relevant bioaccumulation potential.
The calculated Koc value of 12.99 l/kg also does not indicate that a significant geoaccumulation potential is to be expected for methyl acetate. The substance may be washed out
from soil to groundwater by rainwater depending on the elimination in soil by degradation and distribution.
Atmosphere
Due to the atmospheric half-life (t1/2 = 74 to 94 days), abiotic effects on the atmosphere, such as global warming and ozone depletion, are not to be expected in connection with
methyl acetate
For n-Heptane: Log Kow: 4.66; Koc: 2400-8100; Half-life (hr) Air: 52.8; Half-life (hr) Surface Water: 2.9-312; Henry’s atm m3 /mol: 2.06; BOD 5 (if unstated): 1.92; COD: 0.06; BCF:
340-2000; Log BCF: 2.53-3.31.
Atmospheric Fate: Breakdown of n-heptane by sunlight is not expected to be an important fate process. If released to the atmosphere, n-heptane is expected to exist entirely in the
vapor phase, in ambient air. Reactions hydroxyl radicals in the atmosphere have been shown to be important. Night-time reactions with nitrate radicals may contribute to the
atmospheric transformation of n-heptane, especially in urban environments. n-Heptane is not expected to be susceptible to direct breakdown by sunlight
Terrestrial Fate: n-Heptane is expected to be broken down by biological processes in the soil; however, evaporation and adsorption from soil are expected to be a more important fate
processes. n-Heptane will be slightly mobile to immobile in soil.
Aquatic Fate: Breakdown of n-heptane by water is not expected to be an important fate process.
Biological breakdown may occur in water; however, evaporation is expected to be a more important fate process. The evaporation half-life for the substance from a model river is 2.9
hours and from a model pond is 13 days. In aquatic systems, n-heptane may partition from the water column to organic matter in sediments and suspended solids.
Ecotoxicity: Concentration of the substance in aquatic life may be important in aquatic environments. The substance is moderately toxic to goldfish; however n-heptane has low toxicity
to golden orfe, western mosquitofish, Daphnia magna water fleas, and snail. The substance is toxic to opossum shrimp.
For Butane (Synonym: n-Butane): Log Kow: 2.89; Koc: 450-900; Henry s Law Constant: 0.95 atm-cu m/mole, Vapor Pressure: 1820 mm Hg; BCF: 1.9.
Atmospheric Fate: Butane is expected to exist only as a gas in the ambient atmosphere. Gas-phase n-butane is degraded in the atmosphere by reaction with hydroxyl radicals; the
half-life for this reaction in air is estimated to be 6.3 days, (@ 25 C). Butane is not expected to absorb UV light and probably will probably not be broken down directly by sunlight in the
atmosphere. Nighttime reactions with radical species and nitrogen oxides may contribute to the atmospheric transformation of butane.
Terrestrial Fate: Butane is expected to have low mobility in soil. Evaporation from dry soil surfaces is expected to be the main fate process. This substance is expected to be
biologically degraded in soil.
Aquatic Fate: Butane may adsorb to suspended solids and sediment and is expected to occur from water surfaces with an estimated half-life for a model river of 2.2 hours and 3 days,
from a model lake. Biological breakdown in water is expected to occur with complete breakdown estimated to be 34 days to 2-butanone and 2-butanol, (observed in studies).
Breakdown by water and by sunlight in water are not expected to be important fate processes.
Ecotoxicity: The substance is expected to moderately accumulate in aquatic organisms. Butane is moderately toxic to fish, and Daphnia water fleas.
For Propane: Koc 460. log
Kow 2.36.
Henry’s Law constant of 7.07×10-1 atm-cu m/mole, derived from its vapour pressure, 7150 mm Hg, and water solubility, 62.4 mg/L. Estimated BCF: 13.1.
Terrestrial Fate: Propane is expected to have moderate mobility in soil. Volatilization from moist soil surfaces is expected to be an important fate process. Volatilization from dry soil Version No: 7.8 Page 14 of 18
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Ingredient Persistence: Water/Soil Persistence: Air
Ingredient Bioaccumulation
Ingredient Mobility
surfaces is based vapor pressure. Biodegradation may be an important fate process in soil and sediment.
Aquatic Fate: Propane is expected to adsorb to suspended solids and sediment. Volatilization from water surfaces is expected and half-lives for a model river and model lake are
estimated to be 41 minutes and 2.6 days, respectively. Biodegradation may not be an important fate process in water.
Ecotoxicity: The potential for bioconcentration in aquatic organisms is low.
Atmospheric Fate: Propane is expected to exist solely as a gas in the ambient atmosphere. Gas-phase propane is degraded in the atmosphere by reaction with photochemically-
produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 14 days and is not expected to be susceptible to direct photolysis by sunlight.
DO NOT discharge into sewer or waterways.
Persistence and degradability
methyl acetate LOW LOW
butane LOW LOW
propane LOW LOW
iso-butane HIGH HIGH
1,1-difluoroethane LOW LOW
Bioaccumulative potential
methyl acetate LOW (LogKOW = 0.18)
butane LOW (LogKOW = 2.89)
propane LOW (LogKOW = 2.36)
iso-butane LOW (BCF = 1.97)
1,1-difluoroethane LOW (LogKOW = 0.75)
Mobility in soil
methyl acetate MEDIUM (KOC = 3.324)
butane LOW (KOC = 43.79)
propane LOW (KOC = 23.74)
iso-butane LOW (KOC = 35.04)
1,1-difluoroethane LOW (KOC = 35.04)
SECTION 13 Disposal considerations
Waste treatment methods
Product / Packaging disposal
DO NOT allow wash water from cleaning or process equipment to enter drains.
It may be necessary to collect all wash water for treatment before disposal.
In all cases disposal to sewer may be subject to local laws and regulations and these should be considered first.
Where in doubt contact the responsible authority.
Consult State Land Waste Management Authority for disposal.
Discharge contents of damaged aerosol cans at an approved site.
Allow small quantities to evaporate.
DO NOT incinerate or puncture aerosol cans.
Bury residues and emptied aerosol cans at an approved site.
SECTION 14 Transport information
Labels Required
Marine PollutantNO
Land transport (DOT)
UN number or ID number 1950
UN proper shipping name Aerosols, flammable, (each not exceeding 1 L capacity)
Transport hazard class(es)
Class 2.1
Subsidiary riskNot Applicable
Packing group Not Applicable
Environmental hazard Not Applicable
Special precautions for user
Hazard Label 2.1
Special provisionsN82 Version No: 7.8 Page 15 of 18
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Product name Group
Product name Ship Type
Air transport (ICAO-IATA / DGR)
UN number 1950
UN proper shipping name Aerosols, flammable
Transport hazard class(es)
ICAO/IATA Class 2.1
ICAO / IATA SubriskNot Applicable
ERG Code 10L
Packing group Not Applicable
Environmental hazard Not Applicable
Special precautions for user
Special provisions A145 A167 A802
Cargo Only Packing Instructions 203
Cargo Only Maximum Qty / Pack 150 kg
Passenger and Cargo Packing Instructions 203
Passenger and Cargo Maximum Qty / Pack 75 kg
Passenger and Cargo Limited Quantity Packing InstructionsY203
Passenger and Cargo Limited Maximum Qty / Pack 30 kg G
Sea transport (IMDG-Code / GGVSee)
UN number 1950
UN proper shipping name AEROSOLS
Transport hazard class(es)
IMDG Class 2.1
IMDG Subrisk Not Applicable
Packing group Not Applicable
Environmental hazard Not Applicable
Special precautions for user
EMS Number F-D, S-U
Special provisions63 190 277 327 344 381 959
Limited Quantities1000 ml
Transport in bulk according to Annex II of MARPOL and the IBC code
Not Applicable
Transport in bulk in accordance with MARPOL Annex V and the IMSBC Code
methyl acetate Not Available
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
Not Available
butane Not Available
propane Not Available
iso-butane Not Available
1,1-difluoroethane Not Available
Transport in bulk in accordance with the IGC Code
methyl acetate Not Available
Hydrocarbons, C6-C7,
n-alkanes, isoalkanes, cyclics,
<5% n-hexane
Not Available
butane Not Available
propane Not Available
iso-butane Not Available
1,1-difluoroethane Not Available
SECTION 15 Regulatory information
Safety, health and environmental regulations / legislation specific for the substance or mixture
methyl acetate is found on the following regulatory lists Version No: 7.8 Page 16 of 18
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US - Massachusetts - Right To Know Listed Chemicals
US DOE Temporary Emergency Exposure Limits (TEELs)
US NIOSH Recommended Exposure Limits (RELs)
US OSHA Permissible Exposure Limits (PELs) Table Z-1
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US TSCA Chemical Substance Inventory - Interim List of Active Substances
US TSCA Section 4/12 (b) - Sunset Dates/Status
Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane is found on the following regulatory lists
Chemical Footprint Project - Chemicals of High Concern List
International Agency for Research on Cancer (IARC) - Agents Classified by the IARC
Monographs - Not Classified as Carcinogenic
US DOE Temporary Emergency Exposure Limits (TEELs)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US TSCA Chemical Substance Inventory - Interim List of Active Substances
butane is found on the following regulatory lists
Chemical Footprint Project - Chemicals of High Concern List
US - Massachusetts - Right To Know Listed Chemicals
US Department of Homeland Security (DHS) - Chemical Facility Anti-Terrorism
Standards (CFATS) - Chemicals of Interest
US DOE Temporary Emergency Exposure Limits (TEELs)
US NIOSH Recommended Exposure Limits (RELs)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US TSCA Chemical Substance Inventory - Interim List of Active Substances
propane is found on the following regulatory lists
US - Massachusetts - Right To Know Listed Chemicals
US Department of Homeland Security (DHS) - Chemical Facility Anti-Terrorism
Standards (CFATS) - Chemicals of Interest
US DOE Temporary Emergency Exposure Limits (TEELs)
US NIOSH Recommended Exposure Limits (RELs)
US OSHA Permissible Exposure Limits (PELs) Table Z-1
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US TSCA Chemical Substance Inventory - Interim List of Active Substances
iso-butane is found on the following regulatory lists
Chemical Footprint Project - Chemicals of High Concern List
US - Massachusetts - Right To Know Listed Chemicals
US Department of Homeland Security (DHS) - Chemical Facility Anti-Terrorism
Standards (CFATS) - Chemicals of Interest
US DOE Temporary Emergency Exposure Limits (TEELs)
US NIOSH Recommended Exposure Limits (RELs)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US TSCA Chemical Substance Inventory - Interim List of Active Substances
1,1-difluoroethane is found on the following regulatory lists
US - Massachusetts - Right To Know Listed Chemicals
US AIHA Workplace Environmental Exposure Levels (WEELs)
US Department of Homeland Security (DHS) - Chemical Facility Anti-Terrorism
Standards (CFATS) - Chemicals of Interest
US DOE Temporary Emergency Exposure Limits (TEELs)
US EPA Integrated Risk Information System (IRIS)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US Toxicology Excellence for Risk Assessment (TERA) Workplace Environmental
Exposure Levels (WEEL)
US TSCA Chemical Substance Inventory - Interim List of Active Substances
Federal Regulations
Superfund Amendments and Reauthorization Act of 1986 (SARA)
Section 311/312 hazard categories
Flammable (Gases, Aerosols, Liquids, or Solids) Yes
Gas under pressure No
Explosive No
Self-heating No
Pyrophoric (Liquid or Solid) No
Pyrophoric Gas No
Corrosive to metal No
Oxidizer (Liquid, Solid or Gas) No
Organic Peroxide No
Self-reactive No
In contact with water emits flammable gas No
Combustible Dust No
Carcinogenicity No
Acute toxicity (any route of exposure) No
Reproductive toxicity No
Skin Corrosion or Irritation Yes
Respiratory or Skin Sensitization No
Serious eye damage or eye irritation Yes
Specific target organ toxicity (single or repeated exposure) Yes
Aspiration Hazard No
Germ cell mutagenicity No
Simple Asphyxiant No
Hazards Not Otherwise Classified No
US. EPA CERCLA Hazardous Substances and Reportable Quantities (40 CFR 302.4)
None Reported
State Regulations Version No: 7.8 Page 17 of 18
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National Inventory Status
Version
Date of
Update
Sections Updated
US. California Proposition 65
None listed
National Inventory Status
Australia - AIIC / Australia
Non-Industrial Use
Yes
Canada - DSL Yes
Canada - NDSL No (methyl acetate; Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane; butane; propane; iso-butane; 1,1-difluoroethane)
China - IECSC Yes
Europe - EINEC / ELINCS / NLP Yes
Japan - ENCS No (Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane)
Korea - KECI Yes
New Zealand - NZIoC Yes
Philippines - PICCS Yes
USA - TSCA Yes
Taiwan - TCSI Yes
Mexico - INSQ Yes
Vietnam - NCI Yes
Russia - FBEPH Yes
Legend:
Yes = All CAS declared ingredients are on the inventory
No = One or more of the CAS listed ingredients are not on the inventory. These ingredients may be exempt or will require registration.
SECTION 16 Other information
Revision Date 20/03/2023
Initial Date07/04/2022
SDS Version Summary
6.8 20/03/2023
Firefighting measures - Fire Fighter (fire/explosion hazard), Composition / information on ingredients - Ingredients,
Identification of the substance / mixture and of the company / undertaking - Supplier Information
Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or
other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered.
Definitions and abbreviations
PC TWA: Permissible Concentration-Time Weighted Average
PC STEL: Permissible Concentration-Short Term Exposure Limit
IARC: International Agency for Research on Cancer
ACGIH: American Conference of Governmental Industrial Hygienists
STEL: Short Term Exposure Limit
TEEL: Temporary Emergency Exposure Limit
IDLH: Immediately Dangerous to Life or Health Concentrations
ES: Exposure Standard
OSF: Odour Safety Factor
NOAEL :No Observed Adverse Effect Level
LOAEL: Lowest Observed Adverse Effect Level
TLV: Threshold Limit Value
LOD: Limit Of Detection
OTV: Odour Threshold Value
BCF: BioConcentration Factors
BEI: Biological Exposure Index
AIIC: Australian Inventory of Industrial Chemicals
DSL: Domestic Substances List
NDSL: Non-Domestic Substances List
IECSC: Inventory of Existing Chemical Substance in China
EINECS: European INventory of Existing Commercial chemical Substances
ELINCS: European List of Notified Chemical Substances
NLP: No-Longer Polymers
ENCS: Existing and New Chemical Substances Inventory
KECI: Korea Existing Chemicals Inventory
NZIoC: New Zealand Inventory of Chemicals
PICCS: Philippine Inventory of Chemicals and Chemical Substances
TSCA: Toxic Substances Control Act
TCSI: Taiwan Chemical Substance Inventory
INSQ: Inventario Nacional de Sustancias Qu micas
NCI: National Chemical Inventory
FBEPH: Russian Register of Potentially Hazardous Chemical and Biological Substances
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METYFIX 3 SPRAY ADHESIVE AEROSOL, MULTI-PURPOSE SPRAY ADHESIVE
Issue Date: 20/03/2023
Print Date: 20/03/2023 end of SDS