Trademark of affiliates of DuPont de Nemours, Inc. Page 1 of 20
SAFETY DATA SHEET
DDP Specialty Electronic Materials US,
LLC
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Print Date: 05/29/2025
DDP Specialty Electronic Materials US, LLC encourages and expects you to read and understand the
entire (M)SDS, as there is important information throughout the document. We expect you to follow
the precautions identified in this document unless your use conditions would necessitate other
appropriate methods or actions.
1. IDENTIFICATION
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray Insulation Foam US
Recommended use of the chemical and restrictions on use
Identified uses: For industrial use. We recommend that you use this product in a manner consistent
with the listed use. If your intended use is not consistent with the stated use, please contact your sales
or technical service representative.
COMPANY IDENTIFICATION
DDP Specialty Electronic Materials US,
LLC
974 Centre Road, Building 730,
Wilmington DE 19805
UNITED STATES
Customer Information Number: 833-338-7668
SDSQuestion-NA@dupont.com
EMERGENCY TELEPHONE NUMBER
24-Hour Emergency Contact: 1-800-424-9300
Local Emergency Contact: 800-424-9300
2. HAZARDS IDENTIFICATION
Hazard classification
GHS classification in accordance with 29 CFR 1910.1200
Gases under pressure – Liquefied gas
Acute toxicity – Category 4 – Inhalation
Skin irritation – Category 2
Eye irritation – Category 2B
Respiratory sensitisation – Category 1
Skin sensitisation – Category 1
Specific target organ toxicity – single exposure – Category 3
Specific target organ toxicity – repeated exposure – Category 2 – Inhalation
Simple Asphyxiant
Label elements
Hazard pictograms
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Page 2 of 20
Signal word: DANGER!
Hazards
Contains gas under pressure; may explode if heated.
Causes skin and eye irritation.
May cause an allergic skin reaction.
Harmful if inhaled.
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
May cause damage to organs (Respiratory Tract) through prolonged or repeated exposure if inhaled.
May displace oxygen and cause rapid suffocation.
Precautionary statements
Prevention
Do not breathe mist or vapours.
Wash skin thoroughly after handling.
Use only outdoors or in a well-ventilated area.
Contaminated work clothing must not be allowed out of the workplace.
Wear protective gloves.
In case of inadequate ventilation wear respiratory protection.
Response
IF ON SKIN: Wash with plenty of soap and water.
IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON
CENTER/ doctor if you feel unwell.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If skin irritation or rash occurs: Get medical advice/ attention.
If eye irritation persists: Get medical advice/ attention.
If experiencing respiratory symptoms: Call a POISON CENTER/ doctor.
Take off contaminated clothing and wash before reuse.
Storage
Store in a well-ventilated place. Keep container tightly closed.
Store locked up.
Protect from sunlight. Store in a well-ventilated place.
Disposal
Dispose of contents/ container to an approved waste disposal plant.
Other hazards
No data available
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Page 3 of 20
This product is a mixture.
Component CASRN Concentration
Diphenylmethane Diisocyanate, isomers and
homologues
9016-87-9 50.0 – <= 60.0 %
4,4' -Methylenediphenyl diisocyanate 101-68-8 30.0 - <= 40.0 %
trans-1-Chloro-3,3,3-trifluoropropene 102687-65-0 > 1.0 – < 5.0 %
Carbon dioxide 124-38-9 >= 1.0 – < 5.0 %
Nitrogen 7727-37-9 >= 0.1 – < 0.5 %
Note
Note: CAS 101-68-8 is an MDI isomer that is part of CAS 9016-87-9.
The specific chemical identity and/or exact percentage (concentration) of composition has been
withheld as a trade secret.
4. FIRST AID MEASURES
Description of first aid measures
General advice:
First Aid responders should pay attention to self-protection and use the recommended protective
clothing (chemical resistant gloves, splash protection). If potential for exposure exists refer to Section
8 for specific personal protective equipment.
Inhalation: Move person to fresh air. If not breathing, give artificial respiration; if by mouth to mouth
use rescuer protection (pocket mask, etc). If breathing is difficult, oxygen should be administered by
qualified personnel. Call a physician or transport to a medical facility. If breathing has stopped, apply
artifical respiration.
Skin contact: Remove material from skin immediately by washing with soap and plenty of water.
Remove contaminated clothing and shoes while washing. Seek medical attention if irritation persists.
Wash clothing before reuse. An MDI skin decontamination study demonstrated that cleaning very
soon after exposure is important, and that a polyglycol-based skin cleanser or corn oil may be more
effective than soap and water. Discard items which cannot be decontaminated, including leather
articles such as shoes, belts and watchbands. Suitable emergency safety shower facility should be
available in work area.
Eye contact: Immediately flush eyes with water; remove contact lenses, if present, after the first 5
minutes, then continue flushing eyes for at least 15 minutes. Obtain medical attention without delay,
preferably from an ophthalmologist. Suitable emergency eye wash facility should be immediately
available.
Ingestion: If swallowed, seek medical attention. Do not induce vomiting unless directed to do so by
medical personnel.
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Page 4 of 20
Most important symptoms and effects, both acute and delayed:
Aside from the information found under Description of first aid measures (above) and Indication of
immediate medical attention and special treatment needed (below), any additional important
symptoms and effects are described in Section 11: Toxicology Information.
Indication of any immediate medical attention and special treatment needed
Notes to physician: Maintain adequate ventilation and oxygenation of the patient. May cause
respiratory sensitization or asthma-like symptoms. Bronchodilators, expectorants and antitussives
may be of help. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
Respiratory symptoms, including pulmonary edema, may be delayed. Persons receiving significant
exposure should be observed 24-48 hours for signs of respiratory distress. If you are sensitized to
diisocyanates, consult your physician regarding working with other respiratory irritants or sensitizers.
Exposure may increase "myocardial irritability". Do not administer sympathomimetic drugs such as
epinephrine unless absolutely necessary. Treatment of exposure should be directed at the control of
symptoms and the clinical condition of the patient. Excessive exposure may aggravate preexisting
asthma and other respiratory disorders (e.g. emphysema, bronchitis, reactive airways dysfunction
syndrome).
5. FIREFIGHTING MEASURES
Suitable extinguishing media: Water fog or fine spray. Dry chemical fire extinguishers. Carbon
dioxide fire extinguishers. Foam. Alcohol resistant foams (ATC type) are preferred. General purpose
synthetic foams (including AFFF) or protein foams may function, but will be less effective.
Unsuitable extinguishing media: Do not use direct water stream. May spread fire.
Special hazards arising from the substance or mixture
Hazardous combustion products: During a fire, smoke may contain the original material in addition
to combustion products of varying composition which may be toxic and/or irritating. Combustion
products may include and are not limited to: Nitrogen oxides. Isocyanates. Hydrogen cyanide.
Carbon monoxide. Carbon dioxide. Hydrogen halides. Halogenated hydrocarbons.
Unusual Fire and Explosion Hazards: Some components of this product will burn in a fire situation.
Product reacts with water. Reaction may produce heat and/or gases. This reaction may be violent.
Container may rupture from gas generation in a fire situation. Blowing agent vaporizes quickly at room
temperature. Violent steam generation or eruption may occur upon application of direct water stream
to hot liquids. Dense smoke is produced when product burns.
Advice for firefighters
Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Stay
upwind. Keep out of low areas where gases (fumes) can accumulate. Water is not recommended, but
may be applied in large quantities as a fine spray when other extinguishing agents are not available.
Do not use direct water stream. May spread fire. Fight fire from protected location or safe distance.
Consider the use of unmanned hose holders or monitor nozzles. Immediately withdraw all personnel
from the area in case of rising sound from venting safety device or discoloration of the container.
Move container from fire area if this is possible without hazard. Use water spray to cool fire-exposed
containers and fire-affected zone until fire is out. Contain fire water run-off if possible. Fire water run-
off, if not contained, may cause environmental damage. Review the "Accidental Release Measures"
and the "Ecological Information" sections of this (M)SDS.
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Page 5 of 20
Special protective equipment for firefighters: Wear positive-pressure self-contained breathing
apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers,
boots, and gloves). Avoid contact with this material during fire fighting operations. If contact is likely,
change to full chemical resistant fire fighting clothing with self-contained breathing apparatus. If this is
not available, wear full chemical resistant clothing with self-contained breathing apparatus and fight
fire from a remote location. For protective equipment in post-fire or non-fire clean-up situations, refer
to the relevant sections.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures: Isolate area. Keep
unnecessary and unprotected personnel from entering the area. Refer to section 7, Handling, for
additional precautionary measures. Keep personnel out of low areas. Keep personnel out of confined
or poorly ventilated areas. Keep upwind of spill. Ventilate area of leak or spill. Confined space entry
procedures must be followed before entering the area. See Section 10 for more specific information.
Spilled material may cause a slipping hazard. Use appropriate safety equipment. For additional
information, refer to Section 8, Exposure Controls and Personal Protection.
Environmental precautions: Prevent from entering into soil, ditches, sewers, waterways and/or
groundwater. See Section 12, Ecological Information.
Methods and materials for containment and cleaning up: Do NOT use absorbent materials such
as: Cement powder (Note: may generate heat). Contain spilled material if possible. Absorb with
materials such as: Dirt. Vermiculite. Sand. Clay. Collect in suitable and properly labeled open
containers. Isolate area until gas has dispersed. Apply vapor suppression foams until spill can be
cleaned up. Knock down and dilute vapors with water fog or spray. See Section 13, Disposal
Considerations, for additional information.
7. HANDLING AND STORAGE
Precautions for safe handling: Avoid contact with eyes. Avoid breathing vapor. Do not enter
confined spaces unless adequately ventilated. Wash thoroughly after handling. Keep container
closed. Use with adequate ventilation. This material is hygroscopic in nature. See Section 8,
EXPOSURE CONTROLS AND PERSONAL PROTECTION.
Spills of these organic materials on hot fibrous insulations may lead to lowering of the autoignition
temperatures possibly resulting in spontaneous combustion.
Conditions for safe storage: Minimize sources of ignition, such as static build-up, heat, spark or
flame. Flammable vapors may accumulate in some storage situations. Protect from atmospheric
moisture. Store in a dry place. Avoid prolonged exposure to heat and air. Avoid temperatures above
50 C (122 F) See Section 10 for more specific information.
Storage stability
Storage Period: 24 Month
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
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Issue Date: 03/14/2024
Page 6 of 20
8. EXPOSURE CONTROLS/PERSONAL PROTECTIO N
Control parameters
If exposure limits exist, they are listed below. If no exposure limits are displayed, then no values are
applicable.
Component Regulation Type of listing Value
4,4' -Methylenediphenyl
diisocyanate
DUPONT AEL AEL * Vapour 2.5 Parts per billion
DUPONT AEL AEL * Vapour 20 Parts per billion
DUPONT AEL AEL * particulate 0.025 mg/m3
OSHA Z-1 C 0.2 mg/m3 0.02 ppm
OSHA P0 C 0.2 mg/m3 0.02 ppm
NIOSH REL TWA 0.05 mg/m3 0.005 ppm
NIOSH REL C 0.2 mg/m3 0.02 ppm
trans-1-Chloro-3,3,3-
trifluoropropene
US WEEL TWA 800 ppm
Carbon dioxide Dow IHG TWA 5,000 ppm
Dow IHG STEL 30,000 ppm
ACGIH TWA 5,000 ppm
ACGIH STEL 30,000 ppm
OSHA Z-1 TWA 9,000 mg/m3 5,000
ppm
CAL PEL PEL 9,000 mg/m3 5,000
ppm
CAL PEL STEL 54,000 mg/m3 30,000
ppm
NIOSH REL TWA 9,000 mg/m3 5,000
ppm
NIOSH REL ST 54,000 mg/m3 30,000
ppm
Nitrogen ACGIH See Further information
Further information: Asphyxia; (): Adopted values or notations enclosed are those for
which changes are proposed in the NIC; See Notice of Intended Changes (NIC); D:
Simple asphyxiant; see discussion covering Minimal Oxygen Content found in the
'Definitions and Notations' section following the NIC tables
CAL PEL See Further information
Further information: (h): A number of gases and vapors, when present in high
concentrations, act primarily as asphyxiants without other adverse effects. A
concentration limit is not included for each material because the limiting factor is the
available oxygen. (Several of these materials present fire or explosion hazards.)
Exposure controls
Engineering measures: Use only with adequate ventilation. Local exhaust ventilation may be
necessary for some operations. Provide general and/or local exhaust ventilation to control airborne
levels below the exposure guidelines. Exhaust systems should be designed to move the air away
from the source of vapor/aerosol generation and people working at this point. The odor and irritancy
of this material are inadequate to warn of excessive exposure. Lethal concentrations may exist in
areas with poor ventilation.
Individual protection measures
Eye/face protection: Use chemical goggles.
Skin protection
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
Insulation Foam US
Issue Date: 03/14/2024
Page 7 of 20
Hand protection: Use gloves chemically resistant to this material. Examples of preferred glove
barrier materials include: Butyl rubber. Chlorinated polyethylene. Polyethylene. Ethyl vinyl alcohol
laminate ("EVAL"). Examples of acceptable glove barrier materials include: Neoprene.
Nitrile/butadiene rubber ("nitrile" or "NBR"). Polyvinyl chloride ("PVC" or "vinyl"). Viton. NOTICE: The
selection of a specific glove for a particular application and duration of use in a workplace should also
take into account all relevant workplace factors such as, but not limited to: Other chemicals which may
be handled, physical requirements (cut/puncture protection, dexterity, thermal protection), potential
body reactions to glove materials, as well as the instructions/specifications provided by the glove
supplier.
Other protection: Use protective clothing chemically resistant to this material. Selection of specific
items such as face shield, boots, apron, or full body suit will depend on the task.
Respiratory protection: Atmospheric levels should be maintained below the exposure guideline.
When atmospheric levels may exceed the exposure guideline, use an approved air-purifying respirator
equipped with an organic vapor sorbent and a particle filter. For situations where the atmospheric
levels may exceed the level for which an air-purifying respirator is effective, use a positive-pressure
air-supplying respirator (air line or self-contained breathing apparatus). For emergency response or
for situations where the atmospheric level is unknown, use an approved positive-pressure self-
contained breathing apparatus or positive-pressure air line with auxiliary self-contained air supply. In
confined or poorly ventilated areas, use an approved self-contained breathing apparatus or positive
pressure air line with auxiliary self-contained air supply. For escape purposes, carry an approved air-
purifying respirator on person at all times.
The following should be effective types of air-purifying respirators: Organic vapor cartridge with a
particulate pre-filter.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Physical state Liquefied gas
Color brown
Odor musty
Odor Threshold Odor is inadequate warning of excessive exposure.
pH No data available
Melting point/range No data available.
Freezing point No data available.
Boiling point (760 mmHg) No data available
Flash point > 200 C ( > 392 F)
Evaporation Rate (Butyl Acetate
= 1)
Not available
Flammability (solid, gas) Not expected to form explosive dust-air mixtures. No
information available.
Lower explosion limit Liquid.
Upper explosion limit Liquid.
Vapor Pressure Not available
Relative Vapor Density (air = 1) No data available
Relative Density (water = 1) 1.24 at 25 C (77 F) Estimated.
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
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Issue Date: 03/14/2024
Page 8 of 20
Water solubility insoluble
Partition coefficient: n-
octanol/water
No data available
Auto-ignition temperature No data available
Decomposition temperature No data available
Kinematic Viscosity No data available
Explosive properties No data available
Oxidizing properties no oxidising properties
Molecular weight No data available
NOTE: The physical data presented above are typical values and should not be construed as a
specification.
10. STABILITY AND REACTIVITY
Reactivity: No data available
Chemical stability: Stable under recommended storage conditions. See Storage, Section 7.
Possibility of hazardous reactions: Can occur. Elevated temperatures can cause hazardous
polymerization. Polymerization can be catalyzed by: Strong bases. Water.
Conditions to avoid: Exposure to elevated temperatures can cause product to decompose. Elevated
temperatures can cause pressure buildup in closed containers due to the release of blowing agents.
Generation of gas during decomposition can cause pressure in closed systems. Pressure build-up
can be rapid. Avoid moisture. Material reacts slowly with water, releasing carbon dioxide which can
cause pressure buildup and rupture of closed containers. Elevated temperatures accelerate this
reaction.
Incompatible materials: Avoid contact with: Acids. Alcohols. Amines. Water. Ammonia. Bases.
Metal compounds. Moist air. Strong oxidizers. Diisocyanates react with many materials and the rate
of reaction increases with temperature as well as increased contact; these reactions can become
violent. Contact is increased by stirring or if the other material mixes with the diisocyanate.
Diisocyanates are not soluble in water and sink to the bottom, but react slowly at the interface. The
reaction forms carbon dioxide gas and a layer of solid polyurea. Reaction with water will generate
carbon dioxide and heat. Avoid contact with metals such as: Aluminum. Zinc. Brass. Tin. Copper.
Galvanized metals. Avoid contact with absorbent materials such as: Moist organic absorbents. Avoid
unintended contact with polyols. The reaction of polyols and isocyanates generate heat.
Hazardous decomposition products: Decomposition products depend upon temperature, air supply
and the presence of other materials. Gases are released during decomposition.
11. TOXICOLOGICAL INFORMATION
Toxicological information appears in this section when such data is available.
Acute toxicity
Acute oral toxicity
Product name: FROTH-PAK AF 650BF 1.75 HFO ISO Spray
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Issue Date: 03/14/2024
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Product test data not available. Refer to component data.
Acute dermal toxicity
Product test data not available. Refer to component data.
Acute inhalation toxicity
Product test data not available. Refer to component data.
Skin corrosion/irritation
Product test data not available. Refer to component data.
Serious eye damage/eye irritation
Product test data not available. Refer to component data.
Sensitization
Product test data not available. Refer to component data.
Specific Target Organ Systemic Toxicity (Single Exposure)
Product test data not available. Refer to component data.
Specific Target Organ Systemic Toxicity (Repeated Exposure)
Tissue injury in the upper respiratory tract and lungs has been observed in laboratory animals after
repeated excessive exposures to MDI/polymeric MDI aerosols.
Carcinogenicity
Lung tumors have been observed in laboratory animals exposed to respirable aerosol droplets of
MDI/Polymeric MDI (6 mg/m3) for their lifetime. Tumors occurred concurrently with respiratory
irritation and lung injury. Current exposure guidelines are expected to protect against these effects
reported for MDI.
Teratogenicity
In laboratory animals, MDI/polymeric MDI did not cause birth defects; other fetal effects occurred only
at high doses which were toxic to the mother. Contains component(s) which did not cause birth
defects in animals; other fetal effects occurred only at doses toxic to the mother.
Reproductive toxicity
Product test data not available. Refer to component data.
Mutagenicity
Genetic toxicity data on MDI are inconclusive. MDI was weakly positive in some in vitro studies; other
in vitro studies were negative. Animal mutagenicity studies were predominantly negative.
Aspiration Hazard
Product test data not available. Refer to component data.
COMPONENTS INFLUENCING TOXICOLOGY :
Diphenylmethane Diisocyanate, isomers and homologues
Acute oral toxicity
Typical for this family of materials. LD50, Rat, > 10,000 mg/kg
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Issue Date: 03/14/2024
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Acute dermal toxicity
Typical for this family of materials. LD50, Rabbit, > 9,400 mg/kg
Acute inhalation toxicity
LC50, Rat, 4 Hour, dust/mist, 0.49 mg/l
For similar material(s): 4,4′-Methylenediphenyl diisocyanate (CAS 101-68-8). LC50, Rat, 1
Hour, Aerosol, 2.24 mg/l
For similar material(s): 2,4′-Diphenylmethane diisocyanate (CAS 5873-54-1). LC50, Rat, 4
Hour, Aerosol, 0.387 mg/l
Skin corrosion/irritation
Prolonged contact may cause slight skin irritation with local redness.
May stain skin.
Serious eye damage/eye irritation
May cause moderate eye irritation.
May cause slight temporary corneal injury.
Sensitization
Skin contact may cause an allergic skin reaction.
Animal studies have shown that skin contact with isocyanates may play a role in respiratory
sensitization.
May cause allergic respiratory reaction.
MDI concentrations below the exposure guidelines may cause allergic respiratory reactions in
individuals already sensitized.
Asthma-like symptoms may include coughing, difficult breathing and a feeling of tightness in
the chest. Occasionally, breathing difficulties may be life threatening.
Specific Target Organ Systemic Toxicity (Single Exposure)
May cause respiratory irritation.
Route of Exposure: Inhalation
Target Organs: Respiratory Tract
Reproductive toxicity
No relevant data found.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
4,4′ -Methylenediphenyl diisocyanate
Acute oral toxicity
LD50, Rat, > 2,000 mg/kg No deaths occurred at this concentration.
Acute dermal toxicity
LD50, Rabbit, > 9,400 mg/kg
Acute inhalation toxicity
LC50, Rat, 1 Hour, dust/mist, 2.24 mg/l
Skin corrosion/irritation
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Prolonged contact may cause moderate skin irritation with local redness.
Repeated contact may cause moderate skin irritation with local redness.
May stain skin.
Serious eye damage/eye irritation
May cause moderate eye irritation.
May cause slight temporary corneal injury.
Sensitization
Skin contact may cause an allergic skin reaction.
Animal studies have shown that skin contact with isocyanates may play a role in respiratory
sensitization.
May cause allergic respiratory reaction.
MDI concentrations below the exposure guidelines may cause allergic respiratory reactions in
individuals already sensitized.
Asthma-like symptoms may include coughing, difficult breathing and a feeling of tightness in
the chest. Occasionally, breathing difficulties may be life threatening.
Specific Target Organ Systemic Toxicity (Single Exposure)
May cause respiratory irritation.
Route of Exposure: Inhalation
Target Organs: Respiratory Tract
Reproductive toxicity
No relevant data found.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
trans-1-Chloro-3,3,3-trifluoropropene
Acute oral toxicity
Single dose oral LD50 has not been determined.
Acute dermal toxicity
The dermal LD50 has not been determined.
Acute inhalation toxicity
LC50, Rat, 4 Hour, gas, 120000 ppm
Skin corrosion/irritation
Brief contact is essentially nonirritating to skin.
Serious eye damage/eye irritation
No relevant data found.
Sensitization
Did not cause allergic skin reactions when tested in humans.
For respiratory sensitization:
No relevant data found.
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Specific Target Organ Systemic Toxicity (Single Exposure)
Evaluation of available data suggests that this material is not an STOT-SE toxicant.
Reproductive toxicity
No relevant data found.
Aspiration Hazard
Based on available information, aspiration hazard could not be determined.
Carbon dioxide
Acute oral toxicity
Single dose oral LD50 has not been determined.
Acute dermal toxicity
The dermal LD50 has not been determined.
Acute inhalation toxicity
LC50, Rat, 4 hrs, gas, 58750 ppm
Skin corrosion/irritation
No hazard from gas.
Skin contact with the solid (“dry ice”) may cause frostbite.
Liquid may cause frostbite upon skin contact.
Serious eye damage/eye irritation
No hazard from gas.
Eye contact with the solid (“dry ice”) may cause freeze burns.
Liquid may cause frostbite.
Sensitization
No relevant data found.
For respiratory sensitization:
No relevant data found.
Specific Target Organ Systemic Toxicity (Single Exposure)
Available data are inadequate to determine single exposure specific target organ toxicity.
Reproductive toxicity
Available data are inadequate to determine effects on reproduction.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
Nitrogen
Acute oral toxicity
Single dose oral LD50 has not been determined.
Acute dermal toxicity
The dermal LD50 has not been determined.
Acute inhalation toxicity
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No adverse effects are anticipated from inhalation. In confined or poorly ventilated areas,
vapor can easily accumulate and can cause unconsciousness and death due to displacement
of oxygen.
As product: The LC50 has not been determined.
Skin corrosion/irritation
Essentially nonirritating to skin.
Liquid may cause frostbite upon skin contact.
Serious eye damage/eye irritation
Essentially nonirritating to eyes.
Liquid may cause frostbite.
Liquid may cause severe eye irritation with corneal injury. Corneal burns may occur.
Sensitization
For skin sensitization:
No relevant data found.
For respiratory sensitization:
No relevant data found.
Reproductive toxicity
No relevant data found.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
12. ECOLOGICAL INFORMATION
Ecotoxicological information appears in this section when such data is available.
Toxicity
Diphenylmethane Diisocyanate, isomers and homologues
Acute toxicity to fish
The measured ecotoxicity is that of the hydrolyzed product, generally under conditions
maximizing production of soluble species.
Material is practically non-toxic to aquatic organisms on an acute basis
(LC50/EC50/EL50/LL50 >100 mg/L in the most sensitive species tested).
Based on information for a similar material:
LC50, Danio rerio (zebra fish), static test, 96 Hour, > 1,000 mg/l, OECD Test Guideline 203 or
Equivalent
Acute toxicity to aquatic invertebrates
Based on information for a similar material:
EC50, Daphnia magna (Water flea), static test, 24 Hour, > 1,000 mg/l, OECD Test Guideline
202 or Equivalent
Acute toxicity to algae/aquatic plants
Based on information for a similar material:
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NOEC, Desmodesmus subspicatus (green algae), static test, 72 Hour, Growth rate inhibition,
1,640 mg/l, OECD Test Guideline 201 or Equivalent
Toxicity to bacteria
Based on information for a similar material:
EC50, activated sludge, static test, 3 Hour, Respiration rates., > 100 mg/l
Toxicity to soil-dwelling organisms
EC50, Eisenia fetida (earthworms), Based on information for a similar material:, 14 d, > 1,000
mg/kg
Toxicity to terrestrial plants
EC50, Avena sativa (oats), Growth inhibition, 1,000 mg/l
EC50, Lactuca sativa (lettuce), Growth inhibition, 1,000 mg/l
4,4′ -Methylenediphenyl diisocyanate
Acute toxicity to fish
The measured ecotoxicity is that of the hydrolyzed product, generally under conditions
maximizing production of soluble species.
Material is practically non-toxic to aquatic organisms on an acute basis
(LC50/EC50/EL50/LL50 >100 mg/L in the most sensitive species tested).
Based on information for a similar material:
LC50, Danio rerio (zebra fish), static test, 96 Hour, > 1,000 mg/l, OECD Test Guideline 203 or
Equivalent
Acute toxicity to aquatic invertebrates
Based on information for a similar material:
EC50, Daphnia magna (Water flea), static test, 24 Hour, > 1,000 mg/l, OECD Test Guideline
202 or Equivalent
Acute toxicity to algae/aquatic plants
Based on information for a similar material:
NOEC, Desmodesmus subspicatus (green algae), static test, 72 Hour, Growth rate inhibition,
1,640 mg/l, OECD Test Guideline 201 or Equivalent
Toxicity to bacteria
Based on information for a similar material:
EC50, activated sludge, static test, 3 Hour, Respiration rates., > 100 mg/l
Toxicity to soil-dwelling organisms
EC50, Eisenia fetida (earthworms), Based on information for a similar material:, 14 d, > 1,000
mg/kg
Toxicity to terrestrial plants
EC50, Avena sativa (oats), Growth inhibition, 1,000 mg/l
EC50, Lactuca sativa (lettuce), Growth inhibition, 1,000 mg/l
trans-1-Chloro-3,3,3-trifluoropropene
Acute toxicity to fish
Material is slightly toxic to aquatic organisms on an acute basis (LC50/EC50 between 10 and
100 mg/L in the most sensitive species tested).
LC50, Oncorhynchus mykiss (rainbow trout), Static, 96 Hour, 38 mg/l, OECD Test Guideline
203
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Acute toxicity to aquatic invertebrates
EC50, Daphnia magna, 48 Hour, 82 mg/l, OECD Test Guideline 202
Acute toxicity to algae/aquatic plants
EC50, Pseudokirchneriella subcapitata (green algae), 72 Hour, Growth inhibition, 106.7 mg/l
NOEC, Pseudokirchneriella subcapitata (green algae), 72 Hour, Growth rate, 115 mg/l
Carbon dioxide
Acute toxicity to fish
May decrease pH of aquatic systems to < pH 5 which may be toxic to aquatic organisms.
LC0, Oncorhynchus mykiss (rainbow trout), 1 Hour, 240 mg/l, Method Not Specified.
Acute toxicity to aquatic invertebrates
Based on data from similar materials
NOEC, Daphnia magna (Water flea), 48 Hour, > 100 mg/l
Nitrogen
Acute toxicity to fish
Not expected to be acutely toxic to aquatic organisms.
Persistence and degradability
Diphenylmethane Diisocyanate, isomers and homologues
Biodegradability: In the aquatic and terrestrial environment, material reacts with water
forming predominantly insoluble polyureas which appear to be stable. In the atmospheric
environment, material is expected to have a short tropospheric half-life, based on calculations
and by analogy with related diisocyanates.
10-day Window: Not applicable
Biodegradation: 0 %
Exposure time: 28 d
Method: OECD Test Guideline 302C or Equivalent
4,4′ -Methylenediphenyl diisocyanate
Biodegradability: In the aquatic and terrestrial environment, material reacts with water
forming predominantly insoluble polyureas which appear to be stable. In the atmospheric
environment, material is expected to have a short tropospheric half-life, based on calculations
and by analogy with related diisocyanates.
10-day Window: Not applicable
Biodegradation: 0 %
Exposure time: 28 d
Method: OECD Test Guideline 302C or Equivalent
trans-1-Chloro-3,3,3-trifluoropropene
Biodegradability: Material is not readily biodegradable according to OECD/EEC guidelines.
Biodegradation: 0 %
Exposure time: 28 d
Method: OECD Test Guideline 301D
Carbon dioxide
Biodegradability: Biodegradation is not applicable.
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Nitrogen
Biodegradability: Biodegradation is not applicable. May decrease the dissolved oxygen
(DO) content of natural waters.
Bioaccumulative potential
Diphenylmethane Diisocyanate, isomers and homologues
Bioaccumulation: Bioconcentration potential is low (BCF < 100 or Log Pow < 3). Reacts with
water. In the aquatic and terrestrial environment, movement is expected to be limited by its
reaction with water forming predominantly insoluble polyureas.
Bioconcentration factor (BCF): 92 Cyprinus carpio (Carp) 28 d
4,4' -Methylenediphenyl diisocyanate
Bioaccumulation: Bioconcentration potential is low (BCF < 100 or Log Pow < 3).
Partition coefficient: n-octanol/water(log Pow): 4.51 at 22 C
Bioconcentration factor (BCF): 92 Cyprinus carpio (Carp) 28 d
trans-1-Chloro-3,3,3-trifluoropropene
Bioaccumulation: No relevant data found.
Carbon dioxide
Bioaccumulation: Bioconcentration potential is low (BCF < 100 or Log Pow < 3).
Partition coefficient: n-octanol/water(log Pow): 0.83 Measured
Nitrogen
Bioaccumulation: Partitioning from water to n-octanol is not applicable.
Mobility in soil
Diphenylmethane Diisocyanate, isomers and homologues
In the aquatic and terrestrial environment, movement is expected to be limited by its reaction
with water forming predominantly insoluble polyureas.
trans-1-Chloro-3,3,3-trifluoropropene
No relevant data found.
Carbon dioxide
No relevant data found.
Nitrogen
No data available.
13. DISPOSAL CONSIDERATIONS
Disposal methods: DO NOT DUMP INTO ANY SEWERS, ON THE GROUND, OR INTO ANY BODY
OF WATER. All disposal practices must be in compliance with all Federal, State/Provincial and local
laws and regulations. Regulations may vary in different locations. Waste characterizations and
compliance with applicable laws are the responsibility solely of the waste generator. AS YOUR
SUPPLIER, WE HAVE NO CONTROL OVER THE MANAGEMENT PRACTICES OR
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MANUFACTURING PROCESSES OF PARTIES HANDLING OR USING THIS MATERIAL. THE
INFORMATION PRESENTED HERE PERTAINS ONLY TO THE PRODUCT AS SHIPPED IN ITS
INTENDED CONDITION AS DESCRIBED IN MSDS SECTION: Composition Information. FOR
UNUSED & UNCONTAMINATED PRODUCT, the preferred options include sending to a licensed,
permitted: Recycler. Reclaimer. Incinerator or other thermal destruction device. For additional
information, refer to: Handling & Storage Information, MSDS Section 7 Stability & Reactivity
Information, MSDS Section 10 Regulatory Information, MSDS Section 15
14. TRANSPORT INFORMATION
DOT
Proper shipping name Chemical under pressure, n.o.s.(Carbon dioxide, Nitrogen)
UN number UN 3500
Class 2.2
Packing group
Reportable Quantity MDI
Classification for SEA transport (IMO-IMDG):
Proper shipping name CHEMICAL UNDER PRESSURE, N.O.S. (Carbon dioxide,
Nitrogen)
UN number UN 3500
Class 2.2
Packing group
Marine pollutant No
Transport in bulk
according to Annex I or II
of MARPOL 73/78 and the
IBC or IGC Code
Consult IMO regulations before transporting ocean bulk
Classification for AIR transport (IATA/ICAO):
Proper shipping name Chemical under pressure, n.o.s.(Carbon dioxide, Nitrogen)
UN number UN 3500
Class 2.2
Packing group
This information is not intended to convey all specific regulatory or operational
requirements/information relating to this product. Transportation classifications may vary by container
volume and may be influenced by regional or country variations in regulations. Additional
transportation system information can be obtained through an authorized sales or customer service
representative. It is the responsibility of the transporting organization to follow all applicable laws,
regulations and rules relating to the transportation of the material.
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Issue Date: 03/14/2024
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15. REGULATORY INFORMATION
Superfund Amendments and Reauthorization Act of 1986 Title III (Emergency Planning and
Community Right-to-Know Act of 1986) Sections 311 and 312
Gases under pressure
Simple Asphyxiant
Acute toxicity (any route of exposure)
Skin corrosion or irritation
Serious eye damage or eye irritation
Respiratory or skin sensitisation
Specific target organ toxicity (single or repeated exposure)
Superfund Amendments and Reauthorization Act of 1986 Title III (Emergency Planning and
Community Right-to-Know Act of 1986) Section 313
This product contains the following substances which are subject to the reporting requirements of
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 and which are
listed in 40 CFR 372.
Components CASRN
Diphenylmethane Diisocyanate, isomers and homologues 9016-87-9
4,4' -Methylenediphenyl diisocyanate 101-68-8
Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA)
Section 103
Calculated RQ exceeds reasonably attainable upper limit.
Components CASRN RQ (RCRA Code)
4,4' -Methylenediphenyl diisocyanate 101-68-8 5000 lbs RQ
Does not contain HFC.
Compliant with Title 42 Chapter 85 Clean Air Act: Subchapter VII American Innovation and
Manufacturing Act of 2020, and Section 612 US EPA Significant New Alternatives Policy.
This product neither contains, nor was manufactured with a Class I or Class II ODS as defined by the
U.S. Clean Air Act Section 602 (40 CFR 82, Subpt. A, App.A + B).
Pennsylvania Worker and Community Right-To-Know Act:
The following chemicals are listed because of the additional requirements of Pennsylvania law:
Components CASRN
Carbon dioxide 124-38-9
California Prop. 65
This product does not contain any chemicals known to State of California to cause cancer, birth
defects, or any other reproductive harm.
United States TSCA Inventory (TSCA)
All components of this product are in compliance with the Active inventory listing requirements of the
U.S. Toxic Substances Control Act (TSCA) Chemical Substance Inventory.
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16. OTHER INFORMATION
Hazard Rating System
HMIS
Health Flammability
Physical
Hazard
2* 1 3
* = Chronic Effects (See Hazards Identification)
Revision
Identification Number: 12031896 / A749 / Issue Date: 03/14/2024 / Version: 3.3
Most recent revision(s) are noted by the bold, double bars in left-hand margin throughout this
document.
Legend
ACGIH USA. ACGIH Threshold Limit Values (TLV)
AEL * 15 minute TWA
C Ceiling value not be exceeded at any time.
CAL PEL California permissible exposure limits for chemical contaminants (Title 8, Article
107)
Dow IHG Dow Industrial Hygiene Guideline
DUPONT AEL DuPont AEL (Acceptable Exposure Limit)
NIOSH REL USA. NIOSH Recommended Exposure Limits
OSHA P0 USA. Table Z-1-A Limits for Air Contaminants (1989 vacated values)
OSHA Z-1 USA. Occupational Exposure Limits (OSHA) - Table Z-1 Limits for Air
Contaminants
PEL Permissible exposure limit
ST STEL - 15-minute TWA exposure that should not be exceeded at any time during
a workday
STEL Short term exposure limit
TWA 8-hr TWA
US WEEL USA. Workplace Environmental Exposure Levels (WEEL)
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of
Materials; bw - Body weight; CERCLA - Comprehensive Environmental Response, Compensation,
and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the
German Institute for Standardisation; DOT - Department of Transportation; DSL - Domestic
Substances List (Canada); ECx - Concentration associated with x% response; EHS - Extremely
Hazardous Substance; ELx - Loading rate associated with x% response; EmS - Emergency Schedule;
ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x%
growth rate response; ERG - Emergency Response Guide; GHS - Globally Harmonized System; GLP
- Good Laboratory Practice; HMIS - Hazardous Materials Identification System; IARC - International
Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International
Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of
Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -
International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -
International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 -
Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population
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Issue Date: 03/14/2024
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(Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships;
MSHA - Mine Safety and Health Administration; n.o.s. - Not Otherwise Specified; NFPA - National Fire
Protection Association; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No
Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NTP - National
Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for
Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of
Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -
Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of
Chemicals; RQ - Reportable Quantity; SADT - Self-Accelerating Decomposition Temperature; SARA -
Superfund Amendments and Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical
Substance Inventory; TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control
Act (United States); UN - United Nations; UNRTDG - United Nations Recommendations on the
Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative
Information Source and References
This SDS is prepared by Product Regulatory Services and Hazard Communications Groups from
information supplied by internal references within our company.
DDP Specialty Electronic Materials US, LLC urges each customer or recipient of this (M)SDS to study
it carefully and consult appropriate expertise, as necessary or appropriate, to become aware of and
understand the data contained in this (M)SDS and any hazards associated with the product. The
information herein is provided in good faith and believed to be accurate as of the effective date shown
above. However, no warranty, express or implied, is given. Regulatory requirements are subject to
change and may differ between various locations. It is the buyer's/user's responsibility to ensure that
his activities comply with all federal, state, provincial or local laws. The information presented here
pertains only to the product as shipped. Since conditions for use of the product are not under the
control of the manufacturer, it is the buyer's/user's duty to determine the conditions necessary for the
safe use of this product. Due to the proliferation of sources for information such as manufacturer-
specific (M)SDSs, we are not and cannot be responsible for (M)SDSs obtained from any source other
than ourselves. If you have obtained an (M)SDS from another source or if you are not sure that the
(M)SDS you have is current, please contact us for the most current version.
US